1,4-Dibenzylpiperazine

Base Information

• Chemical Name: 1,4-Dibenzylpiperazine
• CAS No.: 1034-11-3
• Molecular Formula: C18H22N2
• Molecular Weight: 266.386
• European Community (EC) Number: 624-500-9
• UNII: 616774W5JF
• DSSTox Substance ID: DTXSID10899765
• Nikkaji Number: J503.930D
• Wikipedia: Dibenzylpiperazine
• Wikidata: Q5272264
• Pharos Ligand ID: A1F3BD3LHQJZ
• ChEMBL ID: CHEMBL162522
• Mol file: 1034-11-3.mol

Synonyms:DBZP compound;N,N'-dibenzylpiperazine

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Chemical Property of 1,4-Dibenzylpiperazine

Chemical Property:

• Vapor Pressure: 7.03E-06mmHg at 25°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 266.178298710
• Heavy Atom Count: 20
• Complexity: 231

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CC2=CC=CC=C2)CC3=CC=CC=C3
• General Description: 1,4-Dibenzylpiperazine is a compound with notable anticocaine activity due to its high affinity for sigma-1 receptors, making it a potential candidate for therapeutic applications targeting cocaine addiction.

Technology Process of 1,4-Dibenzylpiperazine

There total 36 articles about 1,4-Dibenzylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethylene glycol (107-21-1) + benzylamine (100-46-9) → N,N'-dibenzylpiperazine (1034-11-3)

Guidance literature:

With sodium hydrogencarbonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; at 160 ℃; for 6h;

DOI:10.1039/b712685a

Reference yield: 92.0%

piperazine (110-85-0) + benzyl chloride (100-44-7) → N,N'-dibenzylpiperazine (1034-11-3)

Guidance literature:

In ethanol; for 24h; Heating;

Reference yield: 90.0%

piperazine (110-85-0) + benzyl alcohol (100-51-6,185532-71-2) → N,N'-dibenzylpiperazine (1034-11-3)

Guidance literature:

With trimethylamine-N-oxide; tricarbonyl(η⁴-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; In toluene; at 20 - 135 ℃; Schlenk technique; Inert atmosphere; Molecular sieve; Sealed tube;

DOI:10.1021/acscatal.5b02160

upstream raw materials:

piperazine

benzaldehyde

benzyl chloride

ethylene dibromide

Downstream raw materials:

N,N'-dibenzyl-N,N'-1,2-ethanediylbisformamide

N,N'-dibenzyl-2,3-diketopiperazine

piperazine

di(prop-2-ynyl) piperazine-1,4-dicarboxylate