N-(3-ACETYLPHENYL)BENZENESULFONAMIDE

Base Information

• Chemical Name: N-(3-ACETYLPHENYL)BENZENESULFONAMIDE
• CAS No.: 76883-63-1
• Molecular Formula: C14H13NO3S
• Molecular Weight: 275.328
• Mol file: 76883-63-1.mol

Synonyms:N-(3-Acetyl-phenyl)-benzenesulfonamide;N-(3-acetylphenyl)benzenesulfonamide;N-(3-acetylphenyl)benzenesulphonamide;N-(3-acetyl-phenyl)-benzenesulphonamide;

Chemical Property of N-(3-ACETYLPHENYL)BENZENESULFONAMIDE

Chemical Property:

• PSA: 71.62000
• LogP: 3.84380

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-Acetylphenyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of N-(3-ACETYLPHENYL)BENZENESULFONAMIDE

There total 4 articles about N-(3-ACETYLPHENYL)BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(phenylsulfonyl)-1H-benzo[d][1,2,3]triazole (4106-18-7) + 3-Nitroacetophenone (121-89-1) → N-(3-acetylphenyl)benzenesulfonamide (76883-63-1)

Guidance literature:

With chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II); bathophenanthroline; zinc; In 1,4-dioxane; at 100 ℃; for 15h; Schlenk technique; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03535

Reference yield:

1-(3-aminophenyl)ethanone (99-03-6) + benzenesulfonyl chloride (98-09-9) → N-(3-acetylphenyl)benzenesulfonamide (76883-63-1)

Guidance literature:

With pyridine; at 20 ℃; for 8h;

DOI:10.1021/jm0342109

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) → N-(3-acetylphenyl)benzenesulfonamide (76883-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 10 h / Inert atmosphere

2: (1,2-dimethoxyethane)dichloronickel(II); bathophenanthroline; zinc; chloro-trimethyl-silane / 1,4-dioxane / 15 h / 100 °C / Schlenk technique; Sealed tube; Inert atmosphere

With chloro-trimethyl-silane; (1,2-dimethoxyethane)dichloronickel(II); bathophenanthroline; triethylamine; zinc; In 1,4-dioxane; dichloromethane;

DOI:10.1021/acs.orglett.1c03535

upstream raw materials:

1-(3-aminophenyl)ethanone

benzenesulfonyl chloride

1-(phenylsulfonyl)-1H-benzo[d][1,2,3]triazole

3-Nitroacetophenone

Downstream raw materials:

N-{3-[3-(4-amino-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

N-{3-[3-(4-chloro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

N-{3-[3-(2-chloro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

N-{3-[3-(3-nitro-phenyl)-acryloyl]-phenyl}-benzenesulfonamide

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