4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID

Base Information

• Chemical Name: 4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID
• CAS No.: 769132-75-4
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 769132-75-4.mol

Synonyms:

Chemical Property of 4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 3.47E-07mmHg at 25°C
• Boiling Point: 402oC at 760 mmHg
• Flash Point: 196.9oC
• PSA: 60.77000
• Density: 1.267g/cm3
• LogP: 0.81330

Purity/Quality:

99% ^*data from raw suppliers

4-[(2-Hydroxyethyl)(methyl)amino]benzoic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID

There total 5 articles about 4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

D-Xylose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,36562-42-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2) + N-methyl-p-aminobenzoic acid (10541-83-0,937737-33-2) → 4-((2-hydroxyethyl)(methyl)amino)benzoic acid (769132-75-4)

Guidance literature:

With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 16h; chemoselective reaction; Inert atmosphere; Glovebox;

DOI:10.1039/c9gc01195a

Reference yield: 27.0%

ethyl 4-benzoate (149326-00-1) → 4-((2-hydroxyethyl)(methyl)amino)benzoic acid (769132-75-4)

Guidance literature:

ethyl 4-benzoate; With methanol; sodium hydroxide; water; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

p-aminoethylbenzoate (94-09-7) → 4-((2-hydroxyethyl)(methyl)amino)benzoic acid (769132-75-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane / 1 h / 20 °C

1.3: Saturated solution

2.1: sodium tris(acetoxy)borohydride / dichloromethane / Heating / reflux

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran; toluene

4.1: methanol; sodium hydroxide; water / 3 h / 20 °C

With methanol; sodium hydroxide; tetrabutyl ammonium fluoride; water; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

ethyl 4-benzoate

ethyl 4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)(methyl)amino]benzoate

ethyl 4-[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-amino]benzoate

p-aminoethylbenzoate

Refernces

• 1、 -. "FUSED QUINOLINE DERIVATIVE AND USE THEREOF". Page/Page column 117-118. . Retrieved 2008/06/13.