Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)-

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)-
CAS No.:769167-58-0
Molecular Formula:C33H44BrN3O9S
Molecular Weight:738.697
Hs Code.:

Cyclopropanecarboxylic acid,
1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy)
carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen
yl-, methyl ester, (1R,2S)-

Synonyms:

Suppliers and Price of Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)-

There total 16 articles about Cyclopropanecarboxylic acid, 1-[[[(2S,4S)-4-[[(4-bromophenyl)sulfonyl]oxy]-1-[(2S)-2-[[(cyclopentyloxy) carbonyl]amino]-1-oxo-8-nonenyl]-2-pyrrolidinyl]carbonyl]amino]-2-ethen yl-, methyl ester, (1R,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 769167-57-9
(1S,2R)-1-{[(2S,4S)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)-4-hydroxypyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid methyl ester

: 98-58-8
4-bromobenzenesulfonyl chloride

: 769167-58-0
(1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; toluene; for 0.25h; cooling;
DOI:10.1021/jo060285j

Reference yield: 81.0%

: 769167-55-7
(S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid

: 1098199-68-8
C₁₈H₂₁BrN₂O₆S*ClH

: 769167-58-0
(1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester

Guidance literature:: (S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

C₁₈H₂₁BrN₂O₆S*ClH; With triethylamine; In N,N-dimethyl acetamide; at 30 ℃;
DOI:10.1002/cjoc.201180270

Reference yield:

: 862273-27-6
(1R,2S)-1-amino-2-vinylcyclopropane carboxylic acid methyl ester tosylate salt

: 769167-58-0
(1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / sodium 2-ethylhexanoate / H₂O / 4 h / 20 °C

2: 95 percent / potassium tert-butoxide / toluene; tetrahydrofuran / 0.25 h / cooling

With potassium tert-butylate; sodium 2-ethylhexanoic acid; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo060285j