ciluprevir

Base Information

Chemical Name:ciluprevir
CAS No.:1007205-38-0
Molecular Formula:C₄₀H₅₀N₆O₈S
Molecular Weight:774.938
Hs Code.:

Synonyms:

Suppliers and Price of ciluprevir

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ciluprevir

Chemical Property:

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Technology Process of ciluprevir

There total 13 articles about ciluprevir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.9%

: 873223-12-2
14-cyclopentyloxycarbonylamino-18-[2-(2-isopropylaminothiazol-4-yl)-7-methoxyquinolin-4-yloxy]-2,15-dioxo-3,16-diaza-tricyclo[14.3.0.0(4,6)]nonadec-7-ene-4-carboxylic acid methyl ester

: 1007205-38-0,300832-84-2
ciluprevir

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran;
DOI:10.1002/cjoc.201180270

Reference yield:

: 769167-55-7
(S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid

: 1007205-38-0,300832-84-2
ciluprevir

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl acetamide / 0.5 h / 20 °C

1.2: 30 °C

2.1: Hoveyda's catalyst / toluene / 70 - 80 °C / Inert atmosphere

3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 50 - 60 °C

4.1: water; lithium hydroxide / tetrahydrofuran

With water; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl acetamide; toluene;
DOI:10.1002/cjoc.201180270

Reference yield:

: 769167-58-0
(1S,2R)-1-{[(2S,4S)-4-(4-bromo-benzenesulfonyloxy)-1-((S)-2-cyclopentyloxycarbonylamino-oct-7-enoyl)pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid methyl ester

: 1007205-38-0,300832-84-2
ciluprevir

Guidance literature:: Multi-step reaction with 3 steps

1: Hoveyda's catalyst / toluene / 70 - 80 °C / Inert atmosphere

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 50 - 60 °C

3: water; lithium hydroxide / tetrahydrofuran

With water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;
DOI:10.1002/cjoc.201180270