2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole
CAS No.:76959-16-5
Molecular Formula:C14H19NO3
Molecular Weight:249.31
Hs Code.:
DSSTox Substance ID:DTXSID10516521
Wikidata:Q82377989

Synonyms:76959-16-5;SCHEMBL10355389;DTXSID10516521;FRKYNSDNFJIWOY-UHFFFAOYSA-N;2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole;2-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethyl-2-oxazoline

Suppliers and Price of 2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:249.13649347
Heavy Atom Count:18
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1)OC)OC)C2=NC(CO2)(C)C

Technology Process of 2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole

There total 11 articles about 2-(2,3-Dimethoxy-5-methylphenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5653-56-5
2,3-dimethoxy-5-methylbenzoic acid

: 76959-16-5
4,5-dihydro-2-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethyloxazole

Guidance literature:: DOI:10.1016/S0040-4039(00)77857-9

Reference yield:

: 72517-23-8
5-bromo-2,3-dimethoxybenzoic acid

: 76959-16-5
4,5-dihydro-2-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethyloxazole

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / toluene / 2 h / 50 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / SOCl₂ / 0.5 h / Ambient temperature

4: 1) 1.6 M BuLi / 1) THF, hexane, -78 deg C, 1 h, 2) -45 deg C, 1.5 h

With n-butyllithium; thionyl chloride; In dichloromethane; toluene;
DOI:10.1002/hlca.19900730221

Reference yield:

: 107188-91-0
5-bromo-2,3-dimethoxybenzoic acid chloride

: 76959-16-5
4,5-dihydro-2-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / Ambient temperature

2: 82 percent / SOCl₂ / 0.5 h / Ambient temperature

3: 1) 1.6 M BuLi / 1) THF, hexane, -78 deg C, 1 h, 2) -45 deg C, 1.5 h

With n-butyllithium; thionyl chloride; In dichloromethane;
DOI:10.1002/hlca.19900730221