2-Amino-2-methyl-1-propanol

Base Information

• Chemical Name: 2-Amino-2-methyl-1-propanol
• CAS No.: 124-68-5
• Deprecated CAS: 189832-99-3,471883-87-1
• Molecular Formula: C4H11NO
• Molecular Weight: 89.1374
• Hs Code.: 29221990
• European Community (EC) Number: 204-709-8
• ICSC Number: 0285
• NSC Number: 441
• UN Number: 1993
• UNII: LU49E6626Q
• DSSTox Substance ID: DTXSID8027032
• Nikkaji Number: J38.382A
• Wikipedia: Aminomethyl_propanol
• Wikidata: Q32703
• NCI Thesaurus Code: C77445
• RXCUI: 1310544
• Metabolomics Workbench ID: 71508
• ChEMBL ID: CHEMBL122588
• Mol file: 124-68-5.mol

Synonyms:2-amino-2-methyl-1-propanol;2-amino-2-methyl-1-propanol hydrochloride;2-amino-2-methyl-1-propanol mesylate;2-amino-2-methyl-1-propanol nitrate salt;2-amino-2-methyl-1-propanol tosylate;2-amino-2-methylpropanol;aminomethyl propanol

Chemical Property of 2-Amino-2-methyl-1-propanol

Chemical Property:

• Appearance/Colour: white crystals or viscous liquid
• Vapor Pressure: <1 mm Hg ( 25 °C)
• Melting Point: 24-28 °C(lit.)
• Refractive Index: n20/D 1.4455(lit.)
• Boiling Point: 167.2 °C at 760 mmHg
• PKA: 9.7(at 25℃)
• Flash Point: 67.2 °C
• PSA: 46.25000
• Density: 0.93 g/cm³
• LogP: 0.41630
• Storage Temp.: Store at RT.
• Solubility.: H2O: 0.1 M at 20 °C, clear, colorless
• Water Solubility.: miscible
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 89.084063974
• Heavy Atom Count: 6
• Complexity: 42.8
• Transport DOT Label: Combustible Liquid

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-methylpropanol(~95%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,F
• Hazard Codes: Xi,F
• Statements: 36/38-52/53
• Safety Statements: 61-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CC(C)(CO)N
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes. The substance is severely irritating to the skin. The aerosol is irritating to the respiratory tract.
• Effects of Long Term Exposure: Ingestion may cause effects on the liver.
• Uses: 2-Amino-2-methylpropanol is used for the preparation of buffer solutions, suitable for the determination of alkaline phosphatase. 2-Amino-2-methyl-1-propanol is also used in ATR-FTIR spectroscopic investigation of the carbon monoxide absorption characteristics of a series of heterocyclic diamines. 2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

Technology Process of 2-Amino-2-methyl-1-propanol

There total 30 articles about 2-Amino-2-methyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C13H17NO3 → salicylaldehyde (90-02-8) + 2-Amino-2-methyl-1-propanol (124-68-5)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 4h;

DOI:10.1021/jacs.0c01629

Reference yield: 93.0%

carbon monoxide (201230-82-2) + isopropylamine (75-31-0) → 2-Amino-2-methyl-1-propanol (124-68-5)

Guidance literature:

With tricresyl phosphate; hydrogen; palladium diacetate; In diphenylether; at 140 ℃; under 22502.3 - 60006 Torr; Autoclave;

Reference yield: 91.0%

2,2-dimethylaziridine (2658-24-4) → 2-Amino-2-methyl-1-propanol (124-68-5)

Guidance literature:

With sulfuric acid; In water; at 40 - 50 ℃; for 1h; pH=3 - 5.4;

upstream raw materials:

2-nitro-2-methylpropanol

2-methylalanine ethyl ester

2-Aminoisobutyric acid

isobutene

Downstream raw materials:

N-hydroxy-N-(1,1-dimethylethyl)-4-nitrobenzamide

2-{[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-amino}-2-methyl-propan-1-ol

2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline

N-(1,1-dimethyl-2-hydroxyethyl)-p-methoxybenzamide

Refernces

• 1、 Kukharev,Stankevich,Klimenko,Kukhareva. "Cyclization of vinyl ethers derived from amino alcohols". . p. 966 - 969. Retrieved 2007.
• 2、 -. "Preparation method of 2-amino-2-methyl-1-propanol". Paragraph 0056-0059. . Retrieved 2021/03/11.
• 3、 -. "PROCESS FOR PRODUCING SUBSTITUTED AMINO ALCOHOLS". Page/Page column 30; 31; 34-37. . Retrieved 2020/06/01.