Phosphoric acid, 2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:Phosphoric acid, 2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester
CAS No.:770251-21-3
Molecular Formula:C38H48N3O12P
Molecular Weight:769.786
Hs Code.:

Phosphoric acid,
2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet
yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester

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Chemical Property of Phosphoric acid, 2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester

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Technology Process of Phosphoric acid, 2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester

There total 9 articles about Phosphoric acid, 2-[4-[4-[2-[[[(1-acetyl-2,3-dihydro-5-methyl-7-nitro-1H-indol-4-yl)oxy]acet yl]amino]ethoxy]benzoyl]phenoxy]ethyl bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 770251-05-3
(1-acetyl-5-methyl-7-nitroindolin-4-yloxy)acetic acid

: 737816-44-3
phosphoric acid 2-{4-[4-(2-amino-ethoxy)-benzoyl]-phenoxy}-ethyl ester di-tert-butyl ester

: 770251-21-3
phosphoric acid 2-[4-(4-{2-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-acetylamino]-ethoxy}-benzoyl)-phenoxy]-ethyl ester di-tert-butyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 18h;
DOI:10.1016/j.tet.2004.10.094

Reference yield:

: 19499-82-2
5-(N,N-dimethylaminomethyl)indol-4-ol

: 770251-21-3
phosphoric acid 2-[4-(4-{2-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-acetylamino]-ethoxy}-benzoyl)-phenoxy]-ethyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 87 percent / H₂ / Pd-alumina / ethanol / 3800 Torr

2.1: NaBH₃CN; AcOH / 1 h / 15 °C

3.1: 73 percent / AcOH / 1 h / Heating

4.1: 80 percent / aq. NaOH / methanol / 0.75 h / 20 °C

5.1: K₂CO₃ / acetone / 0.25 h

5.2: 90 percent / acetone / 4 h / Heating

6.1: 66 percent / claycop; acetic anhydride / CCl₄ / 4 h / 20 °C

7.1: 75 percent / TFA / 1 h / 20 °C

8.1: 85 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / 18 h / 20 °C

With sodium hydroxide; hydrogen; acetic anhydride; sodium cyanoborohydride; potassium carbonate; copper(II) nitrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium matal-containing silica-supported catalyst; In methanol; tetrachloromethane; ethanol; acetone;
DOI:10.1016/j.tet.2004.10.094

Reference yield:

: 770250-79-8
1-acetyl-5-methylindolin-4-ol

: 770251-21-3
phosphoric acid 2-[4-(4-{2-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-acetylamino]-ethoxy}-benzoyl)-phenoxy]-ethyl ester di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / acetone / 0.25 h

1.2: 90 percent / acetone / 4 h / Heating

2.1: 66 percent / claycop; acetic anhydride / CCl₄ / 4 h / 20 °C

3.1: 75 percent / TFA / 1 h / 20 °C

4.1: 85 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / 18 h / 20 °C

With acetic anhydride; potassium carbonate; copper(II) nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrachloromethane; acetone;
DOI:10.1016/j.tet.2004.10.094