Benzenemethanamine, 4-[(trifluoromethyl)sulfonyl]-

Base Information

• Chemical Name: Benzenemethanamine, 4-[(trifluoromethyl)sulfonyl]-
• CAS No.: 771473-17-7
• Molecular Formula: C8H8F3NO2S
• Molecular Weight: 239.218
• Mol file: 771473-17-7.mol

Synonyms:4-trifluoromethanesulfonylbenzylamine;1-{4-[(trifluoromethyl)sulfonyl]phenyl}methanamine;4-((trifluoromethyl)sulfonyl)benzylamine;4-trifluoromethanesulfonyl-benzylamine;

Chemical Property of Benzenemethanamine, 4-[(trifluoromethyl)sulfonyl]-

Chemical Property:

• Boiling Point: 313.4±42.0 °C(Predicted)
• PSA: 68.54000
• Density: 1.427±0.06 g/cm3(Predicted)
• LogP: 3.21990

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanamine, 4-[(trifluoromethyl)sulfonyl]-

There total 1 articles about Benzenemethanamine, 4-[(trifluoromethyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-[(trifluoromethyl)sulfonyl] benzonitrile (312-21-0) → (4-((trifluoromethyl)sulfonyl)phenyl)methanamine (771473-17-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 19h; Heating / reflux;

Reference yield: 35.0%

(4-((trifluoromethyl)sulfonyl)phenyl)methanamine (771473-17-7) + methyl 3-amino-4-methylthieno[2,3-c]pyridine-2-carboxylate (1572518-03-6) → 3-amino-4-methyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridine-2-carboxamide (1572517-20-4)

Guidance literature:

methyl 3-amino-4-methylthieno[2,3-c]pyridine-2-carboxylate; With potassium hydroxide; In methanol; water; at 50 ℃;

(4-((trifluoromethyl)sulfonyl)phenyl)methanamine; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2019.06.032

Reference yield:

(4-((trifluoromethyl)sulfonyl)phenyl)methanamine (771473-17-7) + 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (1452226-14-0) → 5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno-[2,3-c]pyridazine-6-carboxamide (1451993-15-9)

Guidance literature:

5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

(4-((trifluoromethyl)sulfonyl)phenyl)methanamine; In N,N-dimethyl-formamide; for 0.333333h;

upstream raw materials:

4-[(trifluoromethyl)sulfonyl] benzonitrile

Downstream raw materials:

4-((trifluoromethyl)sulfonyl)benzylamine hydrochloride

5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno-[2,3-c]pyridazine-6-carboxamide

5-amino-4-methyl-3-(morpholinomethyl)-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide

3-amino-4-methyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridine-2-carboxamide