5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

Base Information

• Chemical Name: 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid
• CAS No.: 1452226-14-0
• Molecular Formula: C₉H₉N₃O₂S
• Molecular Weight: 223.255
• Mol file: 1452226-14-0.mol

Synonyms:5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

Chemical Property of 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

There total 5 articles about 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate (1451998-35-8) → 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (1452226-14-0)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 4h;

DOI:10.1002/cmdc.201800710

Reference yield:

C9H8N3O2S(1-)*Li(1+) → 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (1452226-14-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

3-chloro-5,6-dimethylpyridazine-4-carbonitrile (93824-72-7) → 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid (1452226-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / isopropyl alcohol / 0.33 h / 105 °C / Microwave irradiation

2: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

3: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; isopropyl alcohol;

upstream raw materials:

3-chloro-5,6-dimethylpyridazine-4-carbonitrile

ethyl 5-amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylate

5,6-dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile

methyl 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylate

Downstream raw materials:

5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

C₁₉H₁₉FN₄O₂S