4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 77156-77-5
• Molecular Formula: C14H15NO3
• Molecular Weight: 245.27400
• Hs Code.: 2933499090
• Mol file: 77156-77-5.mol

Synonyms:4-Hydroxy-6,8-dimethylquinoline-3-carboxylic ethyl ester;4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate;6,8-Dimethyl-4-hydroxyquinoline-3-carboxylic acid ethyl ester;

Chemical Property of 4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.62E-06mmHg at 25°C
• Boiling Point: 386.1oC at 760 mmHg
• PKA: 2.97±0.50(Predicted)
• Flash Point: 187.3oC
• PSA: 59.42000
• Density: 1.186g/cm3
• LogP: 2.73390

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-hydroxy-6,8-dimethylquinoline-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 4-HYDROXY-6,8-DIMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.6%

ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate (104007-06-9) → ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate (77156-77-5,31601-85-1)

Guidance literature:

In toluene; at 250 ℃; for 0.0833333h; under 31029.7 Torr; Inert atmosphere; Autoclave; Industrial scale;

DOI:10.1021/op500239f

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate (77156-77-5,31601-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: diphenyl ether / 250 °C

In diphenylether; toluene;

DOI:10.1016/j.bmcl.2005.04.040

Reference yield:

2,4-Xylidine (95-68-1) → ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate (77156-77-5,31601-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: diphenyl ether / 250 °C

In diphenylether; toluene;

DOI:10.1016/j.bmcl.2005.04.040

upstream raw materials:

ethyl 4-hydroxy-6,8-dimethylquinoline-3-carboxylate

diethyl 2-ethoxymethylenemalonate

2,4-Xylidine

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