2-[(E)-2-(3-nitrophenyl)vinyl]quinoline

Base Information

• Chemical Name: 2-[(E)-2-(3-nitrophenyl)vinyl]quinoline
• CAS No.: 7251-91-4
• Molecular Formula: C₁₇H₁₂N₂O₂
• Molecular Weight: 276.294
• NSC Number: 13861
• Nikkaji Number: J3.344.861I,J3.374.937F
• Wikidata: Q76305768
• Mol file: 7251-91-4.mol

Synonyms:2-[(E)-2-(3-nitrophenyl)vinyl]quinoline;38101-92-7;(E)-2-(3-Nitrostyryl)quinoline;2-[(E)-2-(3-Nitrophenyl)ethenyl]quinoline;7251-91-4;2-(3-Nitrostyryl)quinoline;NSC13861;R1507;Cambridge id 5573554;Quinoline, 2(m-nitrostyryl)-;SCHEMBL6797017;2-(trans-3-nitrostyryl)quinoline;2-[(E)-3-Nitrostyryl]quinoline;2-(trans-3-nitrostyryl) quinoline;alpha-(m-Nitrobenzylidene)quinaldine;MFCD00024000;NSC-13861;STK285569;AKOS000357521;LS-07813;Quinoline, 2-[2-(3-nitrophenyl)ethenyl]-;CS-0320178;2-[(1E)-2-(3-nitrophenyl)ethenyl]quinoline;2-[(E)-2-(3-Nitrophenyl)ethenyl]quinoline #;Z46024297

Chemical Property of 2-[(E)-2-(3-nitrophenyl)vinyl]quinoline

Chemical Property:

• Vapor Pressure: 4.75E-08mmHg at 25°C
• Boiling Point: 455.4°Cat760mmHg
• Flash Point: 229.2°C
• PSA: 58.71000
• Density: 1.304g/cm³
• LogP: 4.83660
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 276.089877630
• Heavy Atom Count: 21
• Complexity: 391

Purity/Quality:

99% ^*data from raw suppliers

2-[(E)-2-(3-Nitrophenyl)vinyl]quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C=CC3=CC(=CC=C3)[N+](=O)[O-]
• Isomeric SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC(=CC=C3)[N+](=O)[O-]
• Recent EU Clinical Trials: A Phase II Trial of R1507, a Recombinant Human Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor for the treatment of patients with recurrent or refractory Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma and other sarcomas

Technology Process of 2-[(E)-2-(3-nitrophenyl)vinyl]quinoline

There total 1 articles about 2-[(E)-2-(3-nitrophenyl)vinyl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylquinoline (91-63-4) + 3-nitro-benzaldehyde (99-61-6) → 2-(3-nitrostyryl)quinoline (7251-91-4)

Guidance literature:

With acetic acid; at 140 ℃; for 6h; Inert atmosphere;

DOI:10.1134/S107042801102014X

Reference yield: 72.0%

2-(3-nitrostyryl)quinoline (7251-91-4) → 2-(3-aminostyryl)quinoline (108166-00-3)

Guidance literature:

2-(3-nitrostyryl)quinoline; With hydrogenchloride; tin(II) chloride dihdyrate; for 3h; Reflux;

With sodium hydroxide; In water;

DOI:10.1134/S107042801102014X

upstream raw materials:

2-methylquinoline

3-nitro-benzaldehyde

Downstream raw materials:

2-(3-aminostyryl)quinoline

Refernces