2-Chloro-N-ethyl-N-methylpyrimidin-4-amine

Base Information

Chemical Name:2-Chloro-N-ethyl-N-methylpyrimidin-4-amine
CAS No.:77200-07-8
Molecular Formula:C₇H₁₀ClN₃
Molecular Weight:171.63
Hs Code.:
European Community (EC) Number:696-418-1
DSSTox Substance ID:DTXSID80506636
Wikidata:Q82362477
Mol file:77200-07-8.mol

Synonyms:77200-07-8;2-Chloro-N-ethyl-N-methylpyrimidin-4-amine;2-CHLORO-N-ETHYL-N-METHYL-4-PYRIMIDINAMINE;SCHEMBL4256517;DTXSID80506636;WYVQCIMGZVVQER-UHFFFAOYSA-N;AKOS011629011;SB56815;CS-0455581;(2-chloro-pyrimidin-4-yl)-ethyl-methyl-amine;2-Chloro-N-ethyl-N-methyl-4-pyrimidinamine, AldrichCPR

Suppliers and Price of 2-Chloro-N-ethyl-N-methylpyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-chloro-N-ethyl-N-methyl-4-pyrimidinamine
100mg
$ 45.00

ChemBridge Corporation
2-chloro-N-ethyl-N-methyl-4-pyrimidinamine 95%
5 g
$ 133.00

ChemBridge Corporation
2-chloro-N-ethyl-N-methyl-4-pyrimidinamine 95%
1 g
$ 46.00

American Custom Chemicals Corporation
2-CHLORO-N-ETHYL-N-METHYL-4-PYRIMIDINAMINE 95.00%
10G
$ 1994.98

American Custom Chemicals Corporation
2-CHLORO-N-ETHYL-N-METHYL-4-PYRIMIDINAMINE 95.00%
1G
$ 221.55

Total 6 raw suppliers

Chemical Property of 2-Chloro-N-ethyl-N-methylpyrimidin-4-amine

Chemical Property:

Vapor Pressure:0.00147mmHg at 25°C
Boiling Point:296oC at 760 mmHg
Flash Point:132.8oC
PSA：29.02000
Density:1.205g/cm3
LogP:1.58610
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:171.0563250
Heavy Atom Count:11
Complexity:120

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-N-ethyl-N-methyl-4-pyrimidinamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(C)C1=NC(=NC=C1)Cl

Technology Process of 2-Chloro-N-ethyl-N-methylpyrimidin-4-amine

There total 2 articles about 2-Chloro-N-ethyl-N-methylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (5-Bromo-2-chloro-pyrimidin-4-yl)-ethyl-methyl-amine

: Ethyl-methyl-pyrimidin-4-yl-amine

: 77200-07-8
2-chloro-N-ethyl-N-methylpyrimidin-4-amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃; for 0.75h;

Reference yield: 59.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 624-78-2
N-Ethylmethylamine

: 771556-83-3
4-chloro-N-ethyl-N-methylpyrimidin-2-amine

: 77200-07-8
2-chloro-N-ethyl-N-methylpyrimidin-4-amine

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01448

Reference yield:

: 77200-07-8
2-chloro-N-ethyl-N-methylpyrimidin-4-amine

: 1-(4-cyanophenyl)-3-(3-(4-(ethyl(methyl)amino)pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 7 h / 110 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C

3: dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; 1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b01448