624-78-2Relevant academic research and scientific papers
Microchannel reaction process for continuously synthesizing methyl ethylamine
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Paragraph 0018; 0021-0024, (2021/11/14)
The invention discloses a microchannel reaction process for continuously synthesizing methyl ethylamine. Diethylamine is one of the key raw materials of synthetic carbaptene, and can be used for treating moderate's disease. In the synthesis, N -xylylenediamine and diethyl sulfate react or N -phenylenethylamine and dimethyl sulfate are subjected to strong exothermic reaction, so that temperature control is difficult, and amplification production is difficult. As a side reaction increases, purification is difficult. In order to solve the engineering problem, the invention provides a novel process for synthesizing methylethyl amine based on a microchannel reactor. In particular, N -xylylenediamine and diethyl sulfate are used. Or N - phenylmethylene ethylamine and dimethyl sulfate are respectively injected into a micro mixer through a feeding pump, and the reaction parameters are controlled. The process has the advantages of simple and convenient operation, mild and controllable reaction and continuous production, remarkably improves the operation safety, and greatly reduces the operation cost.
ORGANOMETALLIC COMPOUNDS FOR THE DEPOSITION OF HIGH PURITY TIN OXIDE AND DRY ETCHING OF THE TIN OXIDE FILMS AND DEPOSITION REACTORS
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Paragraph 0118, (2021/03/05)
Specific organometallic compounds of Formula I: Qx-Sn-(A1R1'z)4-x or Formula II: Sn(NR2(CH2)nA2)2 useful for the deposition of high purity tin oxide, as well as methods of using such compounds are disclosed. Also disclosed are compositions of organometallic compounds useful for the deposition of high purity tin oxide that in combination improve stability. Also disclosed are processes for dry etching tin oxide with a particular etchant gas and/or a process for dry etching a substrate using a particular etchant gas with a specific additive.
Mild catalytic deoxygenation of amides promoted by thorium metallocene
Eisen, Moris S.,Saha, Sayantani
supporting information, p. 12835 - 12841 (2020/10/05)
The organoactinide-catalyzed (Cp*2ThMe2) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adductsviadeoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*2ThMe2is capable of efficiently catalysing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.
Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae
Matzel, Philipp,Krautschick, Lukas,H?hne, Matthias
, p. 2022 - 2027 (2017/10/07)
Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
High-Purity N-Ethylmethylamine and Process for Preparing Same
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Page/Page column 3, (2011/07/29)
The present invention relates to N-ethylmethylamine having a very high degree of purity, that is to say very low contents of impurities commonly encountered in conventional industrial processes, and also to the process for preparing, on an industrial scale, high-purity N-ethylmethylamine.
Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition
Verheijen, Jeroen C.,Wiig, Kjesten A.,Du, Shoucheng,Connors, Stacie L.,Martin, Ashley N.,Ferreira, Jennifer P.,Slepnev, Vladimir I.,Kochendoerfer, Ulrike
body text, p. 3243 - 3246 (2010/08/06)
Conjugation of the phenol derived from rivastigmine with amphetamines gave access to novel carbamate cholinesterase inhibitors. All compounds possessed increased affinity and selectivity for AChE compared to rivastigmine and were orally bioavailable. Comp
2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
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, (2008/06/13)
The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.
Process for obtaining amines by reduction of amides
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Page/Page column 7, (2008/06/13)
Disclosed is a process for the preparation of primary, secondary and tertiary amines via a catalytic hydrogenation of unsubstituted, N-substituted, and N,N- disubstituted amides. The amide is led, together with an auxiliary amine, in vaporised form in a hydrogen containing gas flow over the catalyst. The process can be carried out at relatively low pressures, between 2 and 50 bars, using typical hydrogenation catalysts like CuCr-type catalysts. The amine is obtained with high yield and high selectivity. The process can be carried out in a continuous fixed bed reactor.
Process for obtaining amines by reduction of amides
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Page/Page column 5, (2008/06/13)
Disclosed is a process for the preparation of primary, secondary and tertiary amines via a catalytic hydrogenation of unsubstituted, N-substituted, and N,N-disubstituted amides. The amide is led, together with an auxiliary amine, in vaporised form in a hydrogen containing gas flow over the catalyst. The process can be carried out at relatively low pressures, between 2 and 50 bars, using typical hydrogenation catalysts like CuCr-type catalysts. The amine is obtained with high yield and high selectivity. The process can be carried out in a continuous fixed bed reactor.
