L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester
CAS No.:77225-89-9
Molecular Formula:C20H30N2O6
Molecular Weight:394.468
Hs Code.:

Synonyms:(S)-3-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester;Boc-Dap(Cbz)-OtBu;tert-butyl 2-[(S)-(tert-butoxycarbonyl)amino]-3-[(carbobenzoxy)amino]propionate;

Suppliers and Price of L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：102.96000
LogP:3.92960

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

There total 5 articles about L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 65710-57-8,81306-93-6
3-{[(benzyloxy)carbonyl]amino}-N-(tert-butoxycarbonyl)-L-alanine

: 75-65-0
tert-butyl alcohol

: 77225-89-9
tert-butyl 2-<(S)-(tert-butoxycarbonyl)amino>-3-<(carbobenzoxy)amino>propionate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.bmcl.2006.08.121

Reference yield:

: 76387-70-7
(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

: 77225-89-9
tert-butyl 2-<(S)-(tert-butoxycarbonyl)amino>-3-<(carbobenzoxy)amino>propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / KOH; K₂CO₃ / tetrahydrofuran; H₂O

2: 84 percent / DCC; DMAP / CH₂Cl₂

With dmap; potassium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.08.121

Reference yield:

: 7536-55-2
N-tert-butyloxycarbonylasparagine

: 77225-89-9
tert-butyl 2-<(S)-(tert-butoxycarbonyl)amino>-3-<(carbobenzoxy)amino>propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / iodosobenzene diacetate / ethyl acetate; acetonitrile; H₂O

2: 94 percent / KOH; K₂CO₃ / tetrahydrofuran; H₂O

3: 84 percent / DCC; DMAP / CH₂Cl₂

With dmap; potassium hydroxide; [bis(acetoxy)iodo]benzene; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile; 1: Hofmann reaction;
DOI:10.1016/j.bmcl.2006.08.121