5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine

Base Information

Chemical Name:5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine
CAS No.:77338-34-2
Molecular Formula:C23H25N3O5
Molecular Weight:423.469
Hs Code.:
DSSTox Substance ID:DTXSID60553906
Wikidata:Q82434630

Synonyms:77338-34-2;5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine;SCHEMBL10723108;DTXSID60553906

Suppliers and Price of 5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:423.17942091
Heavy Atom Count:31
Complexity:656

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)O
Isomeric SMILES:C1CC(=O)N[C@@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O

Technology Process of 5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine

There total 5 articles about 5-Oxo-L-prolyl-L-phenylalanyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 77511-08-1
pyroglutamyl-phenylalanyl-phenylalanine methyl ester

: 77338-34-2
pyroglutamyl-phenylalanyl-phenylalanine

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 1h;

Reference yield:

: 2578-84-9
N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

: 77338-34-2
pyroglutamyl-phenylalanyl-phenylalanine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Et₃N, hydroxybenzotriazole (HOBt) / CH₂Cl₂ / 16 h

2: 45percent HBr/CH₃COOH / 0.5 h

3: Et₃N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h

4: 87 percent / 4 N aq. NaOH / methanol / 1 h / 0 °C

With sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4892-10-8
N-(benzyloxycarbonyl)-L-phenylalanyl-L-phenylalanine methyl ester

: 77338-34-2
pyroglutamyl-phenylalanyl-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: 45percent HBr/CH₃COOH / 0.5 h

2: Et₃N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h

3: 87 percent / 4 N aq. NaOH / methanol / 1 h / 0 °C

With sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; acetic acid; triethylamine; In methanol; N,N-dimethyl-formamide;