4892-10-8

Basic information

• Product Name: N-(benzyloxycarbonyl)phenylalanylphenylalanine methyl ester
• Synonyms: N-(benzyloxycarbonyl)phenylalanylphenylalanine methyl ester
• CAS NO: 4892-10-8
• Molecular Formula: C₂₇H₂₈N₂O₅
• Molecular Weight: 460.52
• Mol File: 4892-10-8.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 687.7°C at 760 mmHg
• Flash Point: 369.7°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 9.19E-19mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: N-(benzyloxycarbonyl)phenylalanylphenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxycarbonyl)phenylalanylphenylalanine methyl ester(4892-10-8)
• EPA Substance Registry System: N-(benzyloxycarbonyl)phenylalanylphenylalanine methyl ester(4892-10-8)

Safety Data

• Hazardous Substances Data: 4892-10-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C27H28N2O5/c1-33-26(31)24(18-21-13-7-3-8-14-21)28-25(30)23(17-20-11-5-2-6-12-20)29-27(32)34-19-22-15-9-4-10-16-22/h2-16,23-24H,17-19H2,1H3,(H,28,30)(H,29,32)/t23-,24-/m0/s1

Upstream product

• 63-91-2 L-phenylalanine 
• 96452-48-1 benzyl pyridin-2-yl carbonate 
• 501-53-1 benzyl chloroformate 
• 1161-13-3 N-Cbz-L-Phe 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 96452-61-8 N-(Benzyloxycarbonyl)-L-phenylalanin-2-pyridylester 
• 117999-37-8 Z-ΔPhe-(S)-Phe-OMe 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 1059596-58-5 N-Cbz-L-phenylalanine p-tolylthiol ester 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 26055-07-2 Z-Phe-OBT 
• 87072-42-2 Z-L-phenylalanine DCHA salt 
• 2578-84-9 N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 183609-76-9 methyl (R)-1-{(S)-2-[(S)-2-amino-3-phenylpropanamido]-3-phenylpropanoyl}pyrrolidine-2-carboxylate 

Relevant articles and documents

An efficient amide-forming reaction using tributyltrichloromethylphosphonium chloride

An efficient and expeditious amide-forming reaction is described via a combination of tributylphosphine and carbon tetrachloride (in situ generation of tributyltrichloromethylphosphonium chloride) in the absence of tertiary amines.

Mechanochemical Synthesis of Dipeptides Using Mg-Al Hydrotalcite as Activating Agent under Solvent-Free Reaction Conditions

Given the high demand for green and sustainable synthetic methods for the formation of amides and peptidic bonds, herein we report the efficient, solvent-free mechanochemical synthesis of dipeptides from N-protected amino acids and amino acid methyl ester

An efficient mechanochemical synthesis of amides and dipeptides using 2,4,6-trichloro-1,3,5-triazine and PPh3

A rapid, facile, and efficient mechanochemical synthesis of amides from carboxylic acids has been developed through an in situ acid activation with 2,4,6-trichloro-1,3,5-triazine and a catalytic amount of PPh3. Under room temperature solvent-drop grinding of the reactants in the presence of an inorganic base, a variety of carboxylic acids including aromatic acids, aliphatic acids, and N-protected α-amino acids undergo amidation to afford amides in moderate to excellent yields. The method is also compatible with Fmoc, Cbz, and Boc protecting groups which yields protected optically active dipeptides without detectable racemization.