3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

Base Information

Chemical Name:3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one
CAS No.:773886-92-3
Molecular Formula:C21H25N3O
Molecular Weight:335.449
Hs Code.:
DSSTox Substance ID:DTXSID401133917

Synonyms:773886-92-3;3-(1-Benzylpiperidin-4-yl)-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one;SCHEMBL2317295;MXJNFSQCMIGUDB-UHFFFAOYSA-N;DTXSID401133917;3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one;1,3,4,5-Tetrahydro-3-[1-(phenylmethyl)-4-piperidinyl]-2H-1,3-benzodiazepin-2-one;3-(1-Benzyl-piperidin-4-yl) 1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one;3-(1-Benzyl-piperidin-4-yl)-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one;3-(1-Benzylpiperidin-4-yl)-4,5-dihydro-1H-benzo [d][1,3]diazepin-2(3H)-one;3-[1-(phenylmethyl)-4-piperidinyl]-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1 H)-one;3-[1-(Phenylmethyl)-4-piperidinyl]-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1H)-one

Suppliers and Price of 3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

Chemical Property:

PSA：35.58000
LogP:3.75500
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:335.199762429
Heavy Atom Count:25
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1N2CCC3=CC=CC=C3NC2=O)CC4=CC=CC=C4

Technology Process of 3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

There total 8 articles about 3-(1-Benzyl-piperidin-4-yl)1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

: N-[2-(2-nitrophenyl)ethyl]-1-(phenylmethyl)-4-amino-piperidine-dihydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 773886-92-3
3-(1-benzylpiperidin-4-yl)-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one

Guidance literature:: N-[2-(2-nitrophenyl)ethyl]-1-(phenylmethyl)-4-amino-piperidine-dihydrochloride; With sodium hydroxide; In water; toluene; at 50 ℃; for 1h;

With hydrogen; nickel; In methanol; at 50 ℃;

1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2.5h; Product distribution / selectivity;

Reference yield: 96.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 208184-80-9
2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide

: 773886-92-3
3-(1-benzylpiperidin-4-yl)-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one

Guidance literature:: 2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide; With sodium tetrahydroborate; sulfuric acid; In ethyleneglycol dimethyl ether; at 0 - 70 ℃; for 5h;

With hydrogenchloride; In water; at 55 - 70 ℃; for 1.5h;

1,1'-carbonyldiimidazole; With sodium hydroxide; hydrogen; nickel; more than 3 stages; Product distribution / selectivity;