N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide

Base Information

Chemical Name:N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide
CAS No.:208184-80-9
Molecular Formula:C20H23N3O3
Molecular Weight:353.421
Hs Code.:
DSSTox Substance ID:DTXSID30367072
Nikkaji Number:J989.241I
Wikidata:Q82152666
Pharos Ligand ID:SXLPKRRH9W9J
ChEMBL ID:CHEMBL305728

Synonyms:N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide;CHEMBL305728;208184-80-9;N-(1-Benzyl-piperidin-4-yl)-2-(2-nitro-phenyl)-acetamide;HMS2834J24;MLS001008051;SCHEMBL2315613;DTXSID30367072;TZOIMAXWWXASDX-UHFFFAOYSA-N;BDBM50064987;STK465514;AKOS001216943;SMR000498232;EN300-22452154;SR-01000291409;SR-01000291409-1;Z32354208;N-(1-benzyl-4-piperidinyl)-2-(2-nitrophenyl)acetamide;N-(1-Benzylpiperidine-4-yl)-2-(2-nitrophenyl)acetamide;2-Nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide

Suppliers and Price of N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide

Chemical Property:

PSA：81.65000
LogP:4.21950
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:353.17394160
Heavy Atom Count:26
Complexity:465

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1NC(=O)CC2=CC=CC=C2[N+](=O)[O-])CC3=CC=CC=C3

Technology Process of N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide

There total 2 articles about N-(1-benzylpiperidin-4-yl)-2-(2-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

: 50541-93-0
4-amino-1-benzylpiperidine

: 3740-52-1
2-(2-nitrophenyl)acetic acid

: 208184-80-9
2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide

Guidance literature:: 2-(2-nitrophenyl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.75h;

4-amino-1-benzylpiperidine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 77.8%

: 50541-93-0
4-amino-1-benzylpiperidine

: 208184-80-9
2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide

Guidance literature:: 2-(2-nitrophenyl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.75h;

4-amino-1-benzylpiperidine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 96.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 208184-80-9
2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide

: 773886-92-3
3-(1-benzylpiperidin-4-yl)-1,3,4,5-tetrahydro-2H-benzo[d][1,3]diazepin-2-one

Guidance literature:: 2-nitro-N-[1-(phenylmethyl)-4-piperidinyl]-phenylacetamide; With sodium tetrahydroborate; sulfuric acid; In ethyleneglycol dimethyl ether; at 0 - 70 ℃; for 5h;

With hydrogenchloride; In water; at 55 - 70 ℃; for 1.5h;

1,1'-carbonyldiimidazole; With sodium hydroxide; hydrogen; nickel; more than 3 stages; Product distribution / selectivity;