Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate
CAS No.:77505-86-3
Molecular Formula:C13H14N2O2S
Molecular Weight:262.332
Hs Code.:
DSSTox Substance ID:DTXSID301219657

Synonyms:ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate;77505-86-3;SCHEMBL3933156;OHAMQMFWKYSVPF-UHFFFAOYSA-N;DTXSID301219657;CDA50586;AKOS034122100;EN300-814042;ethyl2-amino-5-benzyl-1,3-thiazole-4-carboxylate;Ethyl 2-amino-5-(phenylmethyl)-4-thiazolecarboxylate;Z2718938682;4-Thiazolecarboxylic acid, 2-amino-5-(phenylmethyl)-, ethyl ester

Suppliers and Price of Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:262.07759887
Heavy Atom Count:18
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC(=N1)N)CC2=CC=CC=C2

Technology Process of Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

There total 2 articles about Ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 17356-08-0
thiourea

: 292858-05-0
ethyl 3-bromo-2-oxo-4-phenylbutanoate

: 77505-86-3
ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

Guidance literature:: In ethanol; for 2h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 77505-86-3
ethyl 2-amino-5-benzyl-1,3-thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate; chloroform / 13 h / Reflux

2: ethanol / 2 h / Reflux; Inert atmosphere

With copper(ll) bromide; In ethanol; chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2013.02.048