Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.:77612-52-3
Molecular Formula:C9H15NO2
Molecular Weight:169.224
Hs Code.:
DSSTox Substance ID:DTXSID60536698

Synonyms:77612-52-3;Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate;DTXSID60536698;methyl 5-ethyl-3,6-dihydro-1(2H)-pyridinecarboxylate;3-ethyl-1,2,5,6-tetrahydro-pyridine-1-carboxylic acid methyl ester

Suppliers and Price of Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:169.110278721
Heavy Atom Count:12
Complexity:199

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CCCN(C1)C(=O)OC

Technology Process of Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate

There total 1 articles about Methyl 5-ethyl-3,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 60900-14-3
1-benzyl-3-ethyl-1,2,5,6-tetrahydropyridine

: 79-22-1
methyl chloroformate

: 77612-52-3
3-ethyl-1-methoxycarbonyl-1,2,5,6-tetrahydropyridine

: 100-44-7
benzyl chloride

Guidance literature:: In benzene; for 5h; Heating;
DOI:10.1016/S0040-4020(01)88613-0 DOI:10.1021/ja00236a023

Reference yield:

: 77612-52-3
3-ethyl-1-methoxycarbonyl-1,2,5,6-tetrahydropyridine

: 77130-12-2
methyl α-<1-tosylindol-3-acetic(1,2,5,6-tetrahydro-3-ethylpyridine)amide-2yl>acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / MeLi, HCl, Et₃N / diethyl ether / 1 h / 0 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 48 h / 20 °C

3: 97 percent / NaBH₄, NH₄Cl / tetrahydrofuran; methanol / 0.08 h / 20 °C

4: 72 percent / 2,4,6-trimethyl benzoic acid / 3 h / 185 °C / Heating

With hydrogenchloride; sodium tetrahydroborate; mesitylenecarboxylic acid; methyllithium; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)88613-0

Reference yield:

: 77612-52-3
3-ethyl-1-methoxycarbonyl-1,2,5,6-tetrahydropyridine

: 88839-88-7
1-tosylindol-3-ylglyox(1,2,5,6-tetrahydro-3-ethylpyridine)amide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / MeLi, HCl, Et₃N / diethyl ether / 1 h / 0 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 48 h / 20 °C

With hydrogenchloride; methyllithium; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)88613-0