Benzoic acid, 4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino ]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino ]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester
CAS No.:776327-07-2
Molecular Formula:C₃₃H₄₁N₅O₇S
Molecular Weight:651.784
Hs Code.:

Benzoic acid,
4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino
]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester

Synonyms:

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Chemical Property of Benzoic acid, 4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino ]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester

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Technology Process of Benzoic acid, 4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino ]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester

There total 13 articles about Benzoic acid, 4-[[2-(acetylamino)-4-[2-[4-[[(Z)-bis[[(1,1-dimethylethoxy)carbonyl]amino ]methylene]amino]phenyl]ethyl]-5-thiazolyl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 737825-28-4
methyl 4-({2-(acetylamino)-4-[2-(4-aminophenyl)ethyl]-1,3-thiazol-5-yl}methyl)benzoate

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 737825-29-5,776327-07-2
methyl 4-[(2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-amino)phenyl]ethyl}-1,3-thiazol-5-yl)methyl]benzoate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737825-22-8
ethyl 2-amino-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate hydrobromide

: 737825-29-5,776327-07-2
methyl 4-[(2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-amino)phenyl]ethyl}-1,3-thiazol-5-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

3: manganese(IV) oxide / methanol; chloroform / 34 h / 20 °C / Inert atmosphere

4: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 6.5 h / 20 - 70 °C

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1 h / 20 °C / 1140.08 Torr

7: tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

With pyridine; manganese(IV) oxide; lithium borohydride; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; hydrogen; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737825-23-9
ethyl 2-(acetylamino)-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate

: 737825-29-5,776327-07-2
methyl 4-[(2-(acetylamino)-4-{2-[4-({(Z)-[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}-amino)phenyl]ethyl}-1,3-thiazol-5-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium borohydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

2: manganese(IV) oxide / methanol; chloroform / 34 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: palladium diacetate; triethylamine; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 6.5 h / 20 - 70 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 1 h / 20 °C / 1140.08 Torr

6: tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium borohydride; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; hydrogen; palladium diacetate; triethylamine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.02.048