4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one

Base Information

• Chemical Name: 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one
• CAS No.: 77671-26-2
• Molecular Formula: C16H19N3O2
• Molecular Weight: 285.346
• ChEMBL ID: CHEMBL33954
• DSSTox Substance ID: DTXSID70574440
• Wikidata: Q82463477
• Mol file: 77671-26-2.mol

Synonyms:77671-26-2;CHEMBL33954;SCHEMBL11172939;DTXSID70574440;RRWNGKIFTNSSTB-UHFFFAOYSA-N;4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one;1,3-Dihydro-4-methyl-5-[4-(1-piperidinyl)benzoyl]-2H-imidazol-2-one

Chemical Property of 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 285.147726857
• Heavy Atom Count: 21
• Complexity: 458

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)N3CCCCC3

Technology Process of 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one

There total 3 articles about 4-Methyl-5-[4-(piperidin-1-yl)benzoyl]-1,3-dihydro-2H-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

piperidine (110-89-4) + 1,3-dihydro-4-(4-fluorobenzoyl)-5-methyl-2H-imidazol-2-one (77671-25-1) → 1,3-dihydro-4-methyl-5-(4-piperidinobenzoyl)-2H-imidazol-2-one (77671-26-2)

Guidance literature:

for 24h; Heating;

DOI:10.1021/jm00354a017

Reference yield:

1,3-dihydro-4-(4-fluorobenzoyl)-5-methyl-2H-imidazol-2-one (77671-25-1) → 1,3-dihydro-4-methyl-5-(4-piperidinobenzoyl)-2H-imidazol-2-one (77671-26-2)

Guidance literature:

In piperidine; water; isopropyl alcohol;

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → 1,3-dihydro-4-methyl-5-(4-piperidinobenzoyl)-2H-imidazol-2-one (77671-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / AlCl₃ / nitrobenzene / 6 h / 60 - 65 °C

2: 84 percent / 24 h / Heating

With aluminium trichloride; In nitrobenzene;

DOI:10.1021/jm00354a017

upstream raw materials:

piperidine

1,3-dihydro-4-(4-fluorobenzoyl)-5-methyl-2H-imidazol-2-one

4-fluorobenzoyl chloride