1H-Indole-3-acetic acid, a-1H-indol-3-yl-, methyl ester

Base Information

• Chemical Name: 1H-Indole-3-acetic acid, a-1H-indol-3-yl-, methyl ester
• CAS No.: 78205-43-3
• Molecular Formula: C19H16N2O2
• Molecular Weight: 304.34300
• Mol file: 78205-43-3.mol

Synonyms:Methyl bis<3-indolyl>-acetate;Bis-(1H-indol-3-yl)-acetic acid methyl ester;methyl 3,3'-diindolylacetate;methyl 2,2-bis(3'-indolyl)ethanoate;Methyl 3,3'-di-indolylacetate;methyl 2,2-di(1H-indol-3-yl)acetate;

Chemical Property of 1H-Indole-3-acetic acid, a-1H-indol-3-yl-, methyl ester

Chemical Property:

• PSA: 57.88000
• LogP: 3.95410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-3-acetic acid, a-1H-indol-3-yl-, methyl ester

There total 1 articles about 1H-Indole-3-acetic acid, a-1H-indol-3-yl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

indole (120-72-9) + methyl 2-(1,1,1,3,3,3-hexamethyldisilazan-2-yl)-2-methoxyacetate (1069135-00-7) → methyl 2-amino-2-(1H-indol-3-yl)acetate (110317-48-1) + Methyl bis<3-indolyl>-acetate (78205-43-3)

Guidance literature:

indole; methyl 2-(1,1,1,3,3,3-hexamethyldisilazan-2-yl)-2-methoxyacetate; With chloro-trimethyl-silane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;

With water; Further stages.;

DOI:10.1016/j.tet.2008.07.052

Reference yield:

Methyl bis<3-indolyl>-acetate (78205-43-3) → streptindole (88321-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / LiAlH₄ / diethyl ether / 24 h / 20 °C

2: 85 percent / pyridine

With pyridine; lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1016/j.carres.2005.07.019

upstream raw materials:

indole

methyl 2-(1,1,1,3,3,3-hexamethyldisilazan-2-yl)-2-methoxyacetate

Downstream raw materials:

streptindole