2,3-Bis(4-methoxyphenyl)thiophene

Base Information

• Chemical Name: 2,3-Bis(4-methoxyphenyl)thiophene
• CAS No.: 78316-50-4
• Molecular Formula: C18H16O2S
• Molecular Weight: 296.39
• DSSTox Substance ID: DTXSID70464872
• Nikkaji Number: J2.387.615I
• Wikidata: Q82290403
• Mol file: 78316-50-4.mol

Synonyms:2,3-bis(4-methoxyphenyl)thiophene;78316-50-4;SCHEMBL1181119;DTXSID70464872;OCGBUPXBWRLMDC-UHFFFAOYSA-N

Chemical Property of 2,3-Bis(4-methoxyphenyl)thiophene

Chemical Property:

• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 296.08710092
• Heavy Atom Count: 21
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(SC=C2)C3=CC=C(C=C3)OC

Technology Process of 2,3-Bis(4-methoxyphenyl)thiophene

There total 10 articles about 2,3-Bis(4-methoxyphenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,5-bis(4-methoxyphenyl)thiophene-2-carboxylic acid (181309-07-9) → 2,3-Bis(4-methoxyphenyl)thiophene (78316-50-4)

Guidance literature:

With C₁₇H₂₆N₂O; copper; at 180 ℃; for 0.75h;

Reference yield: 83.0%

→ 2,3-Bis(4-methoxyphenyl)thiophene (78316-50-4)

Guidance literature:

Reference yield: 82.0%

C19H18O3S → 2,3-Bis(4-methoxyphenyl)thiophene (78316-50-4)

Guidance literature:

With potassium tert-butylate; oxygen; In toluene; at 80 ℃; for 14h;

DOI:10.1021/acs.orglett.9b00563

upstream raw materials:

4,5-bis(4-methoxyphenyl)thiophene-2-carboxylic acid

1-bromo-4-methoxy-benzene

α,α-diphenyl-thien-3-ylmethanol

1,4-di(4-methoxyphenyl)ethanone

Downstream raw materials:

5-(3-methoxycarbonyl-1-oxo-propyl)-2,3-bis-(4-methoxyphenyl) thiophene

4,4'-(thiene-2,3-diyl)diphenol

N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide