N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide

Base Information

• Chemical Name: N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide
• CAS No.: 696645-18-8
• Molecular Formula: C₂₉H₃₉NO₄SSi
• Molecular Weight: 525.784
• Mol file: 696645-18-8.mol

Synonyms:

Chemical Property of N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide

There total 8 articles about N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-(tert-butyldimethylsilyl)-N-methylhydroxylamine (133710-59-5) + 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl)butanoic acid (696645-11-1) → N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide (696645-18-8)

Guidance literature:

4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl)butanoic acid; With oxalyl dichloride; In acetonitrile;

O-(tert-butyldimethylsilyl)-N-methylhydroxylamine; With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

1,4-di(4-methoxyphenyl)ethanone (120-44-5) → N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide (696645-18-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 88 percent / POCl₃ / 0 - 80 °C

2.1: 84 percent / sodium ethanoate / ethanol / 0 °C

3.1: 77 percent / NaOH; water / ethanol / 1 h / Heating

4.1: 95 percent / Cu; quinolein / 0.75 h / 180 °C

5.1: 88 percent / SnCl₄ / CH₂Cl₂ / 0 - 20 °C

6.1: 40 percent / trifluoroacetic acid; triethylsilane / 18 h / 50 °C

7.1: 75 percent / NaOH; water / ethanol / 2 h / Heating

8.1: oxalyl chloride / acetonitrile

8.2: dimethylamino pyridine; triethylamine / acetonitrile / 0 - 20 °C

With triethylsilane; sodium hydroxide; oxalyl dichloride; C₁₇H₂₆N₂O; water; sodium acetate; tin(IV) chloride; copper; trifluoroacetic acid; trichlorophosphate; In ethanol; dichloromethane; acetonitrile;

Reference yield:

1-(4-methoxyphenyl)-1-chloro-2-(4-methoxyphenyl)-2-formylethylene (39831-04-4) → N-(tertbutyl dimethyl silyloxy) N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide (696645-18-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 84 percent / sodium ethanoate / ethanol / 0 °C

2.1: 77 percent / NaOH; water / ethanol / 1 h / Heating

3.1: 95 percent / Cu; quinolein / 0.75 h / 180 °C

4.1: 88 percent / SnCl₄ / CH₂Cl₂ / 0 - 20 °C

5.1: 40 percent / trifluoroacetic acid; triethylsilane / 18 h / 50 °C

6.1: 75 percent / NaOH; water / ethanol / 2 h / Heating

7.1: oxalyl chloride / acetonitrile

7.2: dimethylamino pyridine; triethylamine / acetonitrile / 0 - 20 °C

With triethylsilane; sodium hydroxide; oxalyl dichloride; C₁₇H₂₆N₂O; water; sodium acetate; tin(IV) chloride; copper; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile;

upstream raw materials:

O-(tert-butyldimethylsilyl)-N-methylhydroxylamine

4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl)butanoic acid

1,4-di(4-methoxyphenyl)ethanone

1-(4-methoxyphenyl)-1-chloro-2-(4-methoxyphenyl)-2-formylethylene

Downstream raw materials:

N-hydroxy-N-methyl 4-(2,3-bis-(4-methoxyphenyl)-thiophen-5-yl) butanamide