4-(2-methoxyphenoxy)benzonitrile

Base Information

• Chemical Name: 4-(2-methoxyphenoxy)benzonitrile
• CAS No.: 78338-67-7
• Molecular Formula: C14H11NO2
• Molecular Weight: 225.247
• Mol file: 78338-67-7.mol

Synonyms:4-(2-Methoxy-phenoxy)-benzoesaeure-nitril;4-(2-Methoxyphenoxy)benzonitrile;4-(2-methoxy-phenoxy)-benzonitrile;4-cyano-2-methoxydiphenylether;4-(2-Methoxy-phenoxy)-benzonitril;4'-cyano-2-methoxydiphenyl ether;

Chemical Property of 4-(2-methoxyphenoxy)benzonitrile

Chemical Property:

• PSA: 42.25000
• LogP: 3.35918

Purity/Quality:

4-(2-Methoxyphenoxy)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxyphenoxy)benzonitrile

There total 8 articles about 4-(2-methoxyphenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromobenzenecarbonitrile (623-00-7) + 2-methoxy-phenol (90-05-1) → 4-(2'-methoxyphenoxy)benzonitrile (78338-67-7)

Guidance literature:

With pyridine; potassium carbonate; copper(II) oxide; at 120 ℃; for 21h;

DOI:10.1021/jo00097a052

Reference yield: 89.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) + 2-methoxy-phenol (90-05-1) → 4-(2'-methoxyphenoxy)benzonitrile (78338-67-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 18h;

Reference yield: 24.0%

N-(p-cyanophenoxy)pyridinium tetrafluoroborate → 4-(4-methoxyphenoxy)benzonitrile (78338-68-8) + 4-(2'-methoxyphenoxy)benzonitrile (78338-67-7) + 4-cyanophenol (767-00-0) + 4-hydroxy-3-(2-methoxyphenyl)benzonitrile (78338-70-2)

Guidance literature:

With methoxybenzene; at 200 ℃; for 24h; Further byproducts given. Yields of byproduct given;

DOI:10.1021/ja00405a043

upstream raw materials:

methoxybenzene

4-bromobenzenecarbonitrile

2-methoxy-phenol

1-(4-iodo-phenoxy)-2-methoxy-benzene

Downstream raw materials:

4-(5-Iodo-2-methoxyphenoxy)benzonitrile

combretastatin D-2

4-(5-Iodo-2-methoxyphenoxy)benzaldehyde

Methyl (Z)-3-<4-(5-iodo-2-methoxyphenoxy)phenyl>acrylate