(S)-N-(2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide

Base Information

• Chemical Name: (S)-N-(2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide
• CAS No.: 784194-02-1
• Molecular Formula: C₂₀H₂₄N₂O₃S
• Molecular Weight: 372.488
• Mol file: 784194-02-1.mol

Synonyms:

Chemical Property of (S)-N-(2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide

Chemical Property:

• Boiling Point: 528.1±60.0 °C(Predicted)
• PKA: 8.90±0.10(Predicted)
• PSA: 76.14000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 4.40940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-N-(2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide

There total 3 articles about (S)-N-(2-(4-(tert-butyl)-4,5-dihydrooxazol-2-yl)phenyl)-1-phenylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline (194350-71-5) + benzenesulfonyl chloride (1939-99-7) → N-[2-(4-tert-butyl-4,5-dihydro-oxazol-2-yl)phenyl]-C-phenylmethanesulfonamide (784194-02-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/ja045557j

Reference yield:

(S)-tert-leucinol (112245-13-3) → N-[2-(4-tert-butyl-4,5-dihydro-oxazol-2-yl)phenyl]-C-phenylmethanesulfonamide (784194-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.0 g / ZnCl₂ / chlorobenzene / 36 h / 130 °C

2: 2.3 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With triethylamine; zinc(II) chloride; In dichloromethane; chlorobenzene;

DOI:10.1021/ja045557j

Reference yield:

anthranilic acid nitrile (1885-29-6) → N-[2-(4-tert-butyl-4,5-dihydro-oxazol-2-yl)phenyl]-C-phenylmethanesulfonamide (784194-02-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.0 g / ZnCl₂ / chlorobenzene / 36 h / 130 °C

2: 2.3 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With triethylamine; zinc(II) chloride; In dichloromethane; chlorobenzene;

DOI:10.1021/ja045557j

upstream raw materials:

2-[(4S)-4-(tert-butyl)-4,5-dihydro-1,3-oxazol-2-yl]aniline

benzenesulfonyl chloride

(S)-tert-leucinol

anthranilic acid nitrile