5-Thiazolecarboxylic acid, 2-[[[4-(acetylamino)phenyl]sulfonyl]amino]-4-methyl-, ethyl ester

Base Information

Chemical Name:5-Thiazolecarboxylic acid, 2-[[[4-(acetylamino)phenyl]sulfonyl]amino]-4-methyl-, ethyl ester
CAS No.:78633-83-7
Molecular Formula:C15H17N3O5S2
Molecular Weight:383.449
Hs Code.:

Synonyms:2-[(N-acetyl-sulfanilyl)-amino]-4-methyl-thiazole-5-carboxylic acid ethyl ester;2-[(N-Acetyl-sulfanilyl)-amino]-4-methyl-thiazol-5-carbonsaeure-aethylester;

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Thiazolecarboxylic acid, 2-[[[4-(acetylamino)phenyl]sulfonyl]amino]-4-methyl-, ethyl ester

Chemical Property:

PSA：151.08000
LogP:3.61420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarboxylic acid, 2-[[[4-(acetylamino)phenyl]sulfonyl]amino]-4-methyl-, ethyl ester

There total 6 articles about 5-Thiazolecarboxylic acid, 2-[[[4-(acetylamino)phenyl]sulfonyl]amino]-4-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 7210-76-6
ethyl-2-amino-4-methylthiazole-5-carboxylate

: 121-60-8
p-acetylaminobenzenesulfonyl chloride

: 78633-83-7
2-(p-Acetylaminobenzenesulfonamido)-4-methyl-5-carboethoxythiazole

Guidance literature:: With pyridine; at 20 ℃; for 48h;
DOI:10.1023/B:COHC.0000023773.23834.ba

Reference yield:

: 141-97-9
ethyl acetoacetate

: 78633-83-7
2-(p-Acetylaminobenzenesulfonamido)-4-methyl-5-carboethoxythiazole

Guidance literature:: Multi-step reaction with 2 steps

1: I₂ / 15 h / 80 - 90 °C

2: pyridine

With pyridine; iodine;

Reference yield:

: 13068-65-0
N-(N-acetyl-sulfanilyl)-S-methoxymethyl-isothiourea

: 78633-83-7
2-(p-Acetylaminobenzenesulfonamido)-4-methyl-5-carboethoxythiazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen chloride; ethanol

2: pyridine

With pyridine; hydrogenchloride; ethanol;