2-Ethyl-3-phenyl-1H-indole

Base Information

• Chemical Name: 2-Ethyl-3-phenyl-1H-indole
• CAS No.: 78825-91-9
• Molecular Formula: C16H15N
• Molecular Weight: 221.302
• DSSTox Substance ID: DTXSID60507924
• Nikkaji Number: J1.710.517E
• Wikidata: Q82364509
• Mol file: 78825-91-9.mol

Synonyms:2-Ethyl-3-phenyl-1H-indole;2-ethyl-3-phenylindole;78825-91-9;DTXSID60507924

Chemical Property of 2-Ethyl-3-phenyl-1H-indole

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 221.120449483
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1=C(C2=CC=CC=C2N1)C3=CC=CC=C3

Technology Process of 2-Ethyl-3-phenyl-1H-indole

There total 20 articles about 2-Ethyl-3-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-(2-benzoylphenyl)propionamide (549500-24-5) → 2-ethyl-3-phenyl-1H-indole (78825-91-9)

Guidance literature:

With samarium; titanium tetrachloride; In tetrahydrofuran; for 1h; Heating;

Reference yield: 61.0%

(E)-1-phenyl2-butanone phenylhydrazone (89188-88-5) → 2-benzyl-3-methyl-1H-indole (19013-50-4) + 2-ethyl-3-phenyl-1H-indole (78825-91-9)

Guidance literature:

With phosphorus trichloride; In benzene; for 1h; Ambient temperature;

Reference yield: 51.0%

1,1-diphenylbutan-2-one O-acetyl oxime (1217438-26-0) → 2-ethyl-3-phenyl-1H-indole (78825-91-9)

Guidance literature:

With caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja100676r

upstream raw materials:

(E)-1-phenyl2-butanone phenylhydrazone

(2R,3S)-2-Ethyl-2-phenyl-2,3-dihydro-1H-indol-3-ol

(2R,3R)-2-Ethyl-2-phenyl-2,3-dihydro-1H-indol-3-ol

benzyl ethyl ketone