N-(2-Benzoylphenyl)propanamide

Base Information

• Chemical Name: N-(2-Benzoylphenyl)propanamide
• CAS No.: 549500-24-5
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• European Community (EC) Number: 632-778-8
• Nikkaji Number: J2.032.473B
• Mol file: 549500-24-5.mol

Synonyms:N-(2-Benzoylphenyl)propanamide;Benzoyl-2 phenyl urethane [French];Benzoyl-2 phenyl urethane;Carbethoxy-amido-2 benzophenone;NIOSH/TX1405600;Propanamide, N-(2-benzoylphenyl)-;Carbethoxy-amido-2 benzophenone [French];TX14056000;2-propionylaminobenzo-phenone;SCHEMBL7032067;N-(2-Benzoylphenyl)propionamide;AKOS002789225;549500-24-5;AQ-407/42033858

Chemical Property of N-(2-Benzoylphenyl)propanamide

Chemical Property:

• Melting Point: 83-84 °C
• Boiling Point: 483.7±28.0 °C(Predicted)
• PKA: 14.54±0.70(Predicted)
• Density: 1.166±0.06 g/cm3(Predicted)
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 253.110278721
• Heavy Atom Count: 19
• Complexity: 321

Purity/Quality:

N-(2-BENZOYLPHENYL)PROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(=O)NC1=CC=CC=C1C(=O)C2=CC=CC=C2

Technology Process of N-(2-Benzoylphenyl)propanamide

There total 5 articles about N-(2-Benzoylphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(phenyl)-2-methylacetamide (620-71-3) + toluene (108-88-3,15644-74-3,16713-13-6) → N-(2-benzoylphenyl)propionamide (549500-24-5)

Guidance literature:

With tert.-butylhydroperoxide; palladium diacetate; In dimethyl sulfoxide; at 100 ℃; for 20h; regioselective reaction;

DOI:10.1021/jo302125h

Reference yield:

propionyl chloride (79-03-8) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → N-(2-benzoylphenyl)propionamide (549500-24-5)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.02.001

Reference yield:

benzaldehyde (100-52-7) + N-(2-iodophenyl)propionamide (60751-75-9) → N-(2-benzoylphenyl)propionamide (549500-24-5)

Guidance literature:

With tert.-butylhydroperoxide; palladium diacetate; silver(l) oxide; In decane; at 120 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201701250

upstream raw materials:

propionic acid anhydride

(2-aminophenyl)(phenyl)methanone

propionyl chloride

heptanoic acid (2-benzoyl-phenyl)-amide

Downstream raw materials:

3-methyl-4-(phenyl)-2-(1H)-quinolinone

heptanoic acid (2-benzoyl-phenyl)-amide

1-Ethyl-3-methyl-4-phenyl-1H-quinolin-2-one

(2-aminophenyl)(phenyl)methanone