Technology Process of 2H-Isoindole-2-acetic acid,
1-[(3,4-dimethoxyphenyl)methyl]-1,3-dihydro-3-oxo-
There total 1 articles about 2H-Isoindole-2-acetic acid,
1-[(3,4-dimethoxyphenyl)methyl]-1,3-dihydro-3-oxo- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide; hydrogen;
palladium on activated charcoal;
Yield given. Multistep reaction;
1.) ethanol, reflux, 1 h, 2.) room temperature;
DOI:10.1039/P19810001654
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 10 g / polyphosphoric acid / 8 h / 70 °C
2: 11 g / toluene-p-sulphonic acid / toluene / 5 h / Heating
3: lithium aluminium hydride / tetrahydrofuran / 5 h / Heating
4: 6 g / acetone / 10 h / 0 °C
5: 0.9 g / aq. 33percent potassium hydroxide / H2O / 3.5 h / Heating
6: 1.5 g / methanol; H2O / 2 h / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; PPA; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; water; acetone; toluene;
DOI:10.1039/P19810001654
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 10 g / polyphosphoric acid / 8 h / 70 °C
2: 11 g / toluene-p-sulphonic acid / toluene / 5 h / Heating
3: lithium aluminium hydride / tetrahydrofuran / 5 h / Heating
4: 6 g / acetone / 10 h / 0 °C
5: 0.9 g / aq. 33percent potassium hydroxide / H2O / 3.5 h / Heating
6: IRA-400 activated resin / H2O / run throuhg a column of resin
7: ethanol / Heating
With
potassium hydroxide; lithium aluminium tetrahydride; PPA; IRA-400 activated resin; toluene-4-sulfonic acid;
In
tetrahydrofuran; ethanol; water; acetone; toluene;
DOI:10.1039/P19810001654
