(S)-1-Benzyl-5-oxopyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1-Benzyl-5-oxopyrrolidine-2-carboxylic acid
• CAS No.: 78964-11-1
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Mol file: 78964-11-1.mol

Synonyms:1-benzyl-5-oxopyrrolidine-2(S)-carboxylic acid;(S)-1-benzyl-2-pyrrolidinone-5-carboxylic acid;(2S)-N-(phenylmethyl)pyroglutamic acid;N-phenylmethylpyroglutamic acid;(S)-N-(phenylmethyl)-5-oxopyrrolidine-2-carboxylic acid;(S)-1-BENZYL-5-CARBOXY-2-PYRROLIDINONE;(R)-1-benzyl-5-oxopyrrolidine-2-carboxylic acid;N-benzyl-(2S)-pyroglutamic acid;(S)-1-benzyl-5-oxopyrrolidine-2-carboxylic acid;(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidinecarboxylic acid;N-benzyl-(S)-pyroglutamic acid;

Chemical Property of (S)-1-Benzyl-5-oxopyrrolidine-2-carboxylic acid

Chemical Property:

• PSA: 57.61000
• LogP: 1.20010

Purity/Quality:

≥95% ^*data from raw suppliers

1-Benzyl-5-oxopyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-Benzyl-5-oxopyrrolidine-2-carboxylic acid

There total 28 articles about (S)-1-Benzyl-5-oxopyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

methyl (2S)-1-benzyl-5-pyrrolidone-2-carboxylate (103301-78-6,143317-59-3,57171-00-3) → N-benzyl-L-pyroglutamic acid (38854-94-3,78964-11-1,7535-59-3)

Guidance literature:

With Me₂AlTeMe; In toluene; at 23 ℃; for 6h;

DOI:10.1016/j.tetlet.2005.05.003

Reference yield: 91.0%

benzyl chloride (100-44-7) + L-Pyroglutamic acid (98-79-3) → N-benzyl-L-pyroglutamic acid (38854-94-3,78964-11-1,7535-59-3)

Guidance literature:

With di-μ-hydroxo-bis[(N,N,N′,N′-tetramethylethylenediamine)copper(II)] chloride; caesium carbonate; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2006.01.050

Reference yield: 91.0%

(S)-tert-butyl 1-benzyl-5-oxopyrrolidine-2-carboxylate (90741-27-8) → N-benzyl-L-pyroglutamic acid (38854-94-3,78964-11-1,7535-59-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 7h;

DOI:10.1016/S0040-4020(01)00684-6

upstream raw materials:

1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

thiosemicarbazide

benzaldehyde

Glutamic acid

Downstream raw materials:

6-(1-Benzyl-5-oxo-pyrrolidin-2-yl)-3-methyl-3H-benzooxazol-2-one

1-Benzyl-4,5-dichlor-1H-pyrrol-2-carbonylchlorid

1-benzyl-5-oxopyrrolidine-2-carbonyl chloride

N-[(2-chloro-4-fluorophenyl)methyl]-5-oxo-1-(phenylmethyl)-prolinamide

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