3-Pyridylalanine

Base Information

• Chemical Name: 3-Pyridylalanine
• CAS No.: 17470-24-5
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol file: 17470-24-5.mol

Synonyms:3-Pyridinealanine(7CI);3-Pyridinepropionic acid, a-amino- (8CI);3-Pyridylalanine;DL-a-Amino-b-(3-pyridine)propanoicacid;NSC 230426;b-(3-Pyridyl)-DL-alanine;

Chemical Property of 3-Pyridylalanine

Chemical Property:

• Vapor Pressure: 2.51E-05mmHg at 25°C
• Melting Point: 262-263 °C
• Refractive Index: 1.581
• Boiling Point: 344.447 °C at 760 mmHg
• PKA: 1.95±0.10(Predicted)
• Flash Point: 162.116 °C
• Density: 1.272 g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-(pyridin-3-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridylalanine

There total 15 articles about 3-Pyridylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-acetyl-(β-3-pyridyl)-DL-alanine (170092-30-5) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1007/s00726-010-0829-3

Reference yield:

3-pyridinecarboxaldehyde (500-22-1) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride; sodium acetate

2: red phosphorus; HI

With phosphorus; hydrogen iodide; sodium acetate; acetic anhydride;

DOI:10.1021/ja01259a059

Reference yield:

Nicotinic acid hydrazide (553-53-7) → 2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine

2: sodium carbonate; glycerol / 160 °C

3: acetic acid anhydride; sodium acetate

4: red phosphorus; HI

With pyridine; phosphorus; hydrogen iodide; sodium acetate; acetic anhydride; sodium carbonate; glycerol;

DOI:10.1021/ja01259a059

upstream raw materials:

5-[3]pyridylmethylene-imidazolidine-2,4-dione

2-(benzoylamino)-3-(3-pyridinyl)-propanoic acid

3,6-bis-[3]pyridylmethylene-piperazine-2,5-dione

acetic anhydride

Downstream raw materials:

2-pyridin-3-ylethylamine

2-(4-Chloro-benzylamino)-3-pyridin-3-yl-propionic acid

N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

C₂₄H₂₂N₂O₄