N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

Base Information

• Chemical Name: N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester
• CAS No.: 1397697-66-3
• Molecular Formula: C₂₄H₂₂N₂O₄
• Molecular Weight: 402.45
• Mol file: 1397697-66-3.mol

Synonyms:N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

Chemical Property of N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

There total 1 articles about N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-(pyridin-3-yl)propanoic acid (17470-24-5,28105-69-3,64090-98-8,70702-47-5) → N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester (1397697-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C

2: chloro-trimethyl-silane / 36 h / 40 °C

With chloro-trimethyl-silane; sodium hydrogencarbonate; In 1,4-dioxane; water;

DOI:10.1007/s00726-010-0829-3

Reference yield: 41.0%

N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester (1397697-66-3) → C24H22N2O4 (1397697-68-5) + (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid (175453-07-3,142994-45-4)

Guidance literature:

With ammonium hydroxide; α-chymotrypsine; ammonium acetate; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; pH=6.9; optical yield given as %ee; Enzymatic reaction;

DOI:10.1007/s00726-010-0829-3

upstream raw materials:

2-amino-3-(pyridin-3-yl)propanoic acid

Downstream raw materials:

C₂₄H₂₂N₂O₄

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid