ethyl 3-oxo-2-acetyl-4-Methylpentanoate

Base Information

• Chemical Name: ethyl 3-oxo-2-acetyl-4-Methylpentanoate
• CAS No.: 79322-87-5
• Molecular Formula: C10H16O4
• Molecular Weight: 200.235
• Mol file: 79322-87-5.mol

Synonyms:2-Isobutyryl-acetessigsaeure-ethylester;2-acetyl-4-methyl-3-oxo-valeric acid ethyl ester;ethyl 3-oxo-2-acetyl-4-methylpentanoate;2-Acetyl-4-methyl-3-oxo-valeriansaeure-aethylester;2-acetyl-4-methyl-3-oxo-pentanoic acid ethyl ester;

Chemical Property of ethyl 3-oxo-2-acetyl-4-Methylpentanoate

Chemical Property:

• PSA: 60.44000
• LogP: 0.97980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-oxo-2-acetyl-4-Methylpentanoate

There total 4 articles about ethyl 3-oxo-2-acetyl-4-Methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl acetoacetate (141-97-9) + isobutyryl chloride (79-30-1) → ethyl 3-oxo-2-acetyl-4-methylpentanoate (79322-87-5)

Guidance literature:

ethyl acetoacetate; With pyridine; magnesium chloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

isobutyryl chloride; In dichloromethane; at 0 - 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1039/c2cc34608g DOI:10.1039/c2cc34608g

Reference yield:

sodium ethyl acetylacetate enolate (1007476-32-5) + isobutyryl chloride (79-30-1) → ethyl 3-oxo-2-acetyl-4-methylpentanoate (79322-87-5)

Guidance literature:

Reference yield:

isobutyryl chloride (79-30-1) + C6H9O3(1-)*C2H5O(1-)*Mg(2+) → ethyl 3-oxo-2-acetyl-4-methylpentanoate (79322-87-5)

Guidance literature:

In diethyl ether;

upstream raw materials:

ethyl acetoacetate

isobutyryl chloride

sodium ethyl acetylacetate enolate

Downstream raw materials:

ethyl 4-methyl-3-oxo-pentanoate

acetic acid

3-methyl-butan-2-one

ethanol

Refernces

• 1、 Betard, Angelique,Wannapaiboon, Suttipong,Fischer, Roland A.. "Assessing the adsorption selectivity of linker functionalized, moisture-stable metal-organic framework thin films by means of an environment-controlled quartz crystal microbalance". supporting information. p. 10493 - 10495. Retrieved 2013/01/15.