Chemical Property of Vernakalant
Chemical Property:
- Boiling Point:479.0±45.0 °C(Predicted)
- PKA:14.79±0.20(Predicted)
- PSA：51.16000
- Density:1.14±0.1 g/cm3(Predicted)
- LogP:2.57860
- XLogP3:2.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:7
- Exact Mass:349.22530847
- Heavy Atom Count:25
- Complexity:394
- Purity/Quality:
-
99%, *data from raw suppliers
Vernakalant 98+% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=C(C=C1)CCOC2CCCCC2N3CCC(C3)O)OC
- Isomeric SMILES:COC1=C(C=C(C=C1)CCO[C@@H]2CCCC[C@H]2N3CC[C@H](C3)O)OC
- Recent ClinicalTrials:Predictive Factors to Effectively Terminate Paroxysmal Atrial Fibrillation by Blocking Atrial Selective Ionic Currents
- Recent EU Clinical Trials:Randomized clinical trial to study effective pharmacological cardioversion of paroxysmal atrial fibrillation by blocking ionic currents atrioselectivas by treatment with vernakalant vs Flecainide
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Description
Vernakalant is a potassium channel blocker that was approved in
Europe in 2010 for treatment of atrial fibrillation (AF), a condition of
cardiac arrhythmia in which the atria of the heart beat irregularly due to
changes in cardiac ion channel function and distribution.
Vernakalant has activity for cardiac Na+ and K+ channels and also for the
atrial-selective Kv1.5 channel. Vernakalant (RSD1235) was characterized
in animal models to assess efficacy, atrial selectivity, and reduction in side effects.
