1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline
• CAS No.: 79461-71-5
• Molecular Formula: C16H17N
• Molecular Weight: 223.318
• DSSTox Substance ID: DTXSID30508084
• Nikkaji Number: J3.598.743F
• Mol file: 79461-71-5.mol

Synonyms:1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline;79461-71-5;SCHEMBL10683163;DTXSID30508084

Chemical Property of 1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 223.136099547
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C(CCC2=CC=CC=C21)C3=CC=CC=C3

Technology Process of 1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline

There total 20 articles about 1-Methyl-2-phenyl-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-phenyl-1,2,3,4-tetrahydroquinoline (24005-23-0) + dimethyl sulfoxide (67-68-5,8070-53-9) → 1-methyl-2-phenyl-1,2,3,4-tetrahydroquinoline (79461-71-5)

Guidance literature:

With formic acid; triethylamine; at 150 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/chem.201303802

Reference yield: 75.0%

3-(2-methoxyphenyl)-N-methyl-1-phenylpropan-1-amine → 1-methyl-2-phenyl-1,2,3,4-tetrahydroquinoline (79461-71-5)

Guidance literature:

With sodium hydride; lithium iodide; In tetrahydrofuran; mineral oil; at 0 - 90 ℃; for 23h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201705916

Reference yield: 60.0%

N-benzyl-N-methyl-2-(2-(phenylselanyl)ethyl)aniline → 1-methyl-2-phenyl-1,2,3,4-tetrahydroquinoline (79461-71-5)

Guidance literature:

With 9,10-dimethoxyanthracene; In acetonitrile; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1016/j.tetlet.2016.08.073

upstream raw materials:

2-phenyl-1,2,3,4-tetrahydroquinoline

methyl iodide

1-methyl-2-phenyl-1,2-dihydroquinoline

1-Methyl-2-(4-oxo-4-phenyl-butyl)-pyridinium; iodide