N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine

Base Information

Chemical Name:N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine
CAS No.:796738-71-1
Molecular Formula:C16H13N5O2
Molecular Weight:307.312
Hs Code.:
Mol file:796738-71-1.mol

Synonyms:N-(2-methyl-4-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine;N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine;2-Pyrimidinamine,N-(2-methyl-4-nitrophenyl)-4-(3-pyridinyl);N-(2-METHYL-4-NITROPHENYL)-4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine;

Suppliers and Price of N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine
50 mg
$ 155.00

TRC
N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine
500 mg
$ 1230.00

ChemScene
2-Pyrimidinamine,N-(2-methyl-4-nitrophenyl)-4-(3-pyridinyl)-
1g
$ 935.00

ChemScene
2-Pyrimidinamine,N-(2-methyl-4-nitrophenyl)-4-(3-pyridinyl)-
500mg
$ 748.00

Chemenu
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 95%+
1g
$ 1459.00

Chemenu
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 95%+
250mg
$ 948.00

Chemenu
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 95%+
100mg
$ 511.00

Total 13 raw suppliers

Chemical Property of N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine

Chemical Property:

Boiling Point:560.7±60.0 °C(Predicted)
PKA:2.66±0.12(Predicted)
PSA：96.52000
Density:1.344±0.06 g/cm3(Predicted)
LogP:4.09500

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine may be a useful intermediate in the preparation of imatinib impurities and phenylpyrimidinamine derivatives related to imatinib mesylate (CAT# G407000) as antitumor agents.

Technology Process of N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine

There total 5 articles about N-(2-Methyl-4-nitrophenyl)-4-(3-pyridinyl)-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 99-52-5
2-methyl-4-nitro-benzenamine

: 483324-01-2
2-chloro-4-(pyridin-3-yl)pyrimidine

: 796738-71-1
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 4h; Inert atmosphere;

Reference yield: 39.8%

: 7149-70-4
2-bromo-5-nitrotoluene

: 66521-66-2
4-pyridin-3-ylpyrimidin-2-ylamine

: 796738-71-1
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 120 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c8cc09558b

Reference yield:

: 55314-16-4,75415-01-9,123367-26-0
3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

: 796738-71-1
N-(2-methyl-4-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / isopropyl alcohol / 24 h / Reflux; Inert atmosphere

2: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; sodium hydroxide; N,N`-dimethylethylenediamine; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1039/c8cc09558b