483324-01-2 Usage
Description
4-(3-Pyridyl)-2-chloropyrimidine, also known as 2-Chloro-4-(3-pyridyl)pyrimidine, is a pyrimidine derivative with the molecular formula C8H6ClN3. It features a chloro group and a pyridyl group as its functional groups, making it a versatile chemical compound used in various applications.
Uses
Used in Pharmaceutical Industry:
4-(3-Pyridyl)-2-chloropyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups allow for the development of biologically active compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(3-Pyridyl)-2-chloropyrimidine serves as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Anticancer Research:
4-(3-Pyridyl)-2-chloropyrimidine is used as a potential anticancer agent in research, due to its ability to be modified and incorporated into compounds that target cancer cells. Its unique structure allows for the exploration of its potential in inhibiting the growth and proliferation of cancerous cells.
Used in Antimicrobial Research:
This chemical compound is also utilized in the development of antimicrobial agents, as its structure can be manipulated to target and combat various microorganisms, contributing to the discovery of new antibiotics and antifungal agents.
Used in Medicinal Chemistry Research:
4-(3-Pyridyl)-2-chloropyrimidine is employed in medicinal chemistry research for its potential to be a key component in the synthesis of novel compounds with therapeutic properties. Its functional groups provide a foundation for further chemical modifications and exploration of its biological activity.
Used in Organic Chemistry Research:
In the field of organic chemistry, 4-(3-Pyridyl)-2-chloropyrimidine is used in various research applications, including the study of reaction mechanisms, synthesis techniques, and the development of new organic compounds with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 483324-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,3,3,2 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 483324-01:
(8*4)+(7*8)+(6*3)+(5*3)+(4*2)+(3*4)+(2*0)+(1*1)=142
142 % 10 = 2
So 483324-01-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClN3/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H
483324-01-2Relevant articles and documents
SYNTHESIS OF 6-METHYL-N1-(4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)BENZENE-1,3-DIAMINE
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Page/Page column 35, (2021/04/23)
Processes and useful intermediates for the synthesis of the tyrosine kinase inhibitors Formula (II) nilotinib and Formula (IV) imatinib. Key intermediates, method for their synthesis and their use in a divergent synthesis, making use of a Curtius rearrangement, to nilotinib and imatinib are described.
As Hedgehog signal transduction pyrimidine amines and pyridine amine inhibitors
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Paragraph 0437-0441; 0967-0971, (2019/06/26)
The invention relates to pyrimidinamine and pyridinamine Hedgehog signal conduction inhibitors. The inhibitors are compounds with the structure represented by formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to a medicinal use of the above compounds as hedgehog signal conduction inhibitors.
Novel 4-(2-pyrimidinylamino)benzamide derivatives as potent hedgehog signaling pathway inhibitors
Xin, Minhang,Zhang, Liandi,Tu, Chongxing,Tang, Feng,Wen, Jun
, p. 5029 - 5036 (2018/09/27)
A series of novel hedgehog signaling pathway inhibitors have been designed and synthesized based on our previously reported scaffold of 4-(2-pyrimidinylamino)benzamide. The Hh signaling pathway inhibitory activities were evaluated by Gli-luciferase reporter method and most compounds showed more potent inhibitory activities than vismodegib. Three compounds were picked out to evaluated in vivo for their PK properties, and compound 23b bearing a 2-pyridyl A-ring and (morpholin-4-yl)methylene at 3-position of D-ring demonstrated satisfactory PK properties. This study suggested the 4-(2-pyrimidinylamino)benzamides were a series of potent Hh signaling pathway inhibitors, deserving to further structural optimization.
