N-BENZYL-2-HYDROXY-BENZAMIDE

Base Information

• Chemical Name: N-BENZYL-2-HYDROXY-BENZAMIDE
• CAS No.: 20919-36-2
• Molecular Formula: C14H13 N O2
• Molecular Weight: 227.263
• Hs Code.: 2924299090
• Mol file: 20919-36-2.mol

Synonyms:Salicylamide,N-benzyl- (7CI,8CI); 2-Hydroxy-N-phenylmethylbenzamide;N-Benzyl-2-hydroxybenzamide; N-Benzylsalicylamide

Chemical Property of N-BENZYL-2-HYDROXY-BENZAMIDE

Chemical Property:

• Vapor Pressure: 9.7E-09mmHg at 25°C
• Melting Point: 136 °C
• Boiling Point: 450.7°Cat760mmHg
• PKA: 8.51±0.30(Predicted)
• Flash Point: 226.4°C
• PSA: 52.82000
• Density: 1.202g/cm³
• LogP: 2.89700

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyl-2-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL-2-HYDROXY-BENZAMIDE

There total 23 articles about N-BENZYL-2-HYDROXY-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzylamine (100-46-9) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → N-benzylsalicylamide (20919-36-2)

Guidance literature:

With dihydroxy-methyl-borane; water; In o-xylene; for 14h; Reflux;

DOI:10.1021/ol401537f

Reference yield: 86.0%

benzylamine (100-46-9) + 2-hydroxy-benzoic acid ethyl ester (118-61-6) → N-benzylsalicylamide (20919-36-2)

Guidance literature:

With phenylboronic acid; In neat (no solvent); at 60 ℃; for 0.75h; Reagent/catalyst; Solvent; Microwave irradiation; Green chemistry;

DOI:10.1039/c7ra11434f

Reference yield: 83.0%

benzylamine (100-46-9) + salicylamide (65-45-2) → N-benzylsalicylamide (20919-36-2)

Guidance literature:

With benzoic acid; In para-xylene; at 130 ℃; for 8h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201400068

upstream raw materials:

phenyl Salicylate

benzylamine

2-hydroxy-benzoic acid ethyl ester

methyl salicylate

Downstream raw materials:

3-Benzyl-2-phenyl-2,3-dihydro-benzo[e][1,3,2]oxazaphosphinin-4-one

benzylamine

salicylic acid

1,2,3,4,5,6-hexa{[(2'-benzylamino-formyl)phenoxyl]methyl}-benzene