4-Phenylpiperidine-4-carboxamide

Base Information

• Chemical Name: 4-Phenylpiperidine-4-carboxamide
• CAS No.: 80139-80-6
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.26800
• DSSTox Substance ID: DTXSID201301653
• Nikkaji Number: J304.098D

Synonyms:4-phenylpiperidine-4-carboxamide;4-phenyl-4-piperidinecarboxamide;80139-80-6;SCHEMBL476403;JPUKONSIEHCAQA-UHFFFAOYSA-N;DTXSID201301653;AKOS010826069;FT-0708284;EN300-146589;A831167

Chemical Property of 4-Phenylpiperidine-4-carboxamide

Chemical Property:

• Melting Point: 154 - 155 °C
• Boiling Point: 409.8±45.0 °C(Predicted)
• PSA: 55.12000
• Density: 1.113±0.06 g/cm3(Predicted)
• LogP: 1.82220
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 204.126263138
• Heavy Atom Count: 15
• Complexity: 228

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1(C2=CC=CC=C2)C(=O)N

Technology Process of 4-Phenylpiperidine-4-carboxamide

There total 3 articles about 4-Phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide (84176-76-1) → 4-carbamoyl-4-phenylpiperidine (80139-80-6)

Guidance literature:

With palladium on carbon; hydrogen; In ethanol;

DOI:10.1016/j.bmcl.2010.08.047

Reference yield: 81.0%

4-phenyl-piperidine-4-carboxylic acid benzylamide (94308-71-1) → 4-carbamoyl-4-phenylpiperidine (80139-80-6)

Guidance literature:

With trifluorormethanesulfonic acid; In toluene; at 150 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tetlet.2010.07.022

Reference yield:

→ 4-carbamoyl-4-phenylpiperidine (80139-80-6)

Guidance literature:

1-Benzylverb., H2 (Pd);

DOI:10.1135/cccc19753904

upstream raw materials:

4-phenyl-piperidine-4-carboxylic acid benzylamide

1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide

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