1-Benzyl-4-phenylpiperidine-4-carboxamide

Base Information

• Chemical Name: 1-Benzyl-4-phenylpiperidine-4-carboxamide
• CAS No.: 84176-76-1
• Molecular Formula: C19H22 N2 O
• Molecular Weight: 294.396
• Hs Code.: 2933399090
• European Community (EC) Number: 282-343-8
• NSC Number: 73397
• DSSTox Substance ID: DTXSID00233098
• Nikkaji Number: J333.062A
• Wikidata: Q83114441
• Mol file: 84176-76-1.mol

Synonyms:1-Benzyl-4-phenylpiperidine-4-carboxamide;84176-76-1;EINECS 282-343-8;1-benzyl-4-phenyl-4-piperidinecarboxamide;NSC73397;SCHEMBL476242;DTXSID00233098;NSC 73397;NSC-73397;4-phenyl-1-(phenylmethyl)-4-piperidinecarboxamide;EN300-12637307

Chemical Property of 1-Benzyl-4-phenylpiperidine-4-carboxamide

Chemical Property:

• Vapor Pressure: 1.9E-09mmHg at 25°C
• Boiling Point: 482°C at 760 mmHg
• Flash Point: 245.3°C
• PSA: 46.33000
• Density: 1.146g/cm³
• LogP: 3.34390
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 294.173213330
• Heavy Atom Count: 22
• Complexity: 362

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)N)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4-phenylpiperidine-4-carboxamide

There total 3 articles about 1-Benzyl-4-phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5) → 1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide (84176-76-1)

Guidance literature:

With sulfuric acid; acetic acid; In toluene; for 6h; Industry scale;

Reference yield:

N,N-bis(2-chloro-ethyl)-benzenemethanamine (55-51-6) + Benzeneacetamide (103-81-1) → 1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide (84176-76-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 80 ℃;

DOI:10.1016/j.bmcl.2010.08.047

Reference yield:

1-benzyl-4-phenyl-piperidine-4-carboxylic acid (61886-17-7) → 1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide (84176-76-1)

Guidance literature:

With thionyl chloride; Behandeln des Reaktionsgemisches mit NH₃;

DOI:10.1039/jr9500002173

upstream raw materials:

1-benzyl-4-cyano-4-phenylpiperidine

1-benzyl-4-phenyl-piperidine-4-carboxylic acid

N,N-bis(2-chloro-ethyl)-benzenemethanamine

Benzeneacetamide

Downstream raw materials:

4-carbamoyl-4-phenylpiperidine

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