2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid
• CAS No.: 80537-08-2
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• European Community (EC) Number: 836-363-4
• DSSTox Substance ID: DTXSID80512050
• Nikkaji Number: J2.354.714G
• Wikidata: Q82371133
• Mol file: 80537-08-2.mol

Synonyms:2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid;80537-08-2;Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 2-methyl-;MFCD16658390;2-Methylpyrazolo[1,5-a]pyridine-3-carboxylicacid;SCHEMBL951965;2-Methyl pyrazolo[1,5-a]pyridine-3-carboxylic acid;DTXSID80512050;BPDIACCVSJFNFN-UHFFFAOYSA-N;AMY30438;AKOS016008291;AS-67992;SY335445;CS-0230446;EN300-103989;2-methyl-3-pyrazolo[1,5-a]pyridine -carboxylic acid;Z1255375072

Chemical Property of 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

Chemical Property:

• PSA: 54.60000
• LogP: 1.34090
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.058577502
• Heavy Atom Count: 13
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

2-Methylpyrazolo[1,5-a]pyridine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=NN2C=CC=CC2=C1C(=O)O

Technology Process of 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

There total 5 articles about 2-Methylpyrazolo[1,5-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester (30843-10-8) → 2-methylpyrazolo<1,5-a>pyridine-3-carboxylic acid (80537-08-2)

Guidance literature:

With sodium hydroxide; 1) water, 30 min, reflux, 2) 95percent ethanol, 20 min, reflux, 3) HCl;

Reference yield: 84.0%

→ 2-methylpyrazolo<1,5-a>pyridine-3-carboxylic acid (80537-08-2)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 70 ℃;

Reference yield:

Ethyl 2-butynoate (4341-76-8) + N-aminopyridin-1-ium iodide (6295-87-0) → 2-methylpyrazolo<1,5-a>pyridine-3-carboxylic acid (80537-08-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

upstream raw materials:

2-methyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester

N-aminopyridin-1-ium iodide

Methyl 2-butynoate

Ethyl 2-butynoate

Downstream raw materials:

5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

N-benzyl-2-{2-methylpyrazolo[1,5-a]pyridin-3-yl}-5,6,7,8-tetrahydroquinazolin-4-amine

2-Methyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid [2-(2-hydroxy-ethyl)-phenyl]-amide

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