5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

Base Information

Chemical Name:5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine
CAS No.:1610966-00-1
Molecular Formula:C₁₉H₁₇FN₆O
Molecular Weight:364.382
Hs Code.:

Synonyms:5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

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Chemical Property of 5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

There total 3 articles about 5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1610966-66-9
3-(4,6-dichloro-5-fluoropyrimidin-2-yl)-2-methylpyrazolo[1,5-a]pyridine

: 104-94-9
4-methoxy-aniline

: 1610966-00-1
5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

Guidance literature:: 3-(4,6-dichloro-5-fluoropyrimidin-2-yl)-2-methylpyrazolo[1,5-a]pyridine; 4-methoxy-aniline; In ethanol; at 100 ℃; for 3h; Sealed tube;

With ammonium hydroxide; In Isopropyl acetate; at 100 ℃; for 24h; Sealed tube;

Reference yield:

: 80537-08-2
2-methylpyrazolo<1,5-a>pyridine-3-carboxylic acid

: 1610966-00-1
5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-iodo-succinimide / methanol; chloroform / 0.33 h / 20 °C

2.1: isopropyl magnesium chloride - lithium chloride complex / tetrahydrofuran / 0.5 h / 0 °C

2.2: 1 h / 0 °C

3.1: ethanol / 3 h / 100 °C / Sealed tube

3.2: 24 h / 100 °C / Sealed tube

With N-iodo-succinimide; isopropyl magnesium chloride - lithium chloride complex; In tetrahydrofuran; methanol; ethanol; chloroform;

Reference yield:

: 1610966-65-8
3-iodo-2-methylpyrazolo[1,5-a]pyridine

: 1610966-00-1
5-fluoro-N-(4-methoxyphenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)pyrimidine-4,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl magnesium chloride - lithium chloride complex / tetrahydrofuran / 0.5 h / 0 °C

1.2: 1 h / 0 °C

2.1: ethanol / 3 h / 100 °C / Sealed tube

2.2: 24 h / 100 °C / Sealed tube

With isopropyl magnesium chloride - lithium chloride complex; In tetrahydrofuran; ethanol;