Benzoic acid, 3-amino-, phenylmethyl ester

Base Information

• Chemical Name: Benzoic acid, 3-amino-, phenylmethyl ester
• CAS No.: 80787-43-5
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Mol file: 80787-43-5.mol

Synonyms:

Chemical Property of Benzoic acid, 3-amino-, phenylmethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 3-amino-, phenylmethyl ester

There total 10 articles about Benzoic acid, 3-amino-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl 3-(tert-butoxycarbonylamino) benzoate (123986-60-7) → 3-aminobenzoic acid benzyl ester (80787-43-5)

Guidance literature:

benzyl 3-(tert-butoxycarbonylamino) benzoate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; Cooling with ice;

DOI:10.1016/j.tet.2011.12.030

Reference yield: 87.0%

meta-aminobenzoic acid (99-05-8,159139-79-4) + benzyl alcohol (100-51-6,185532-71-2) → 3-aminobenzoic acid benzyl ester (80787-43-5)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; for 5h;

DOI:10.1002/ardp.200700177

Reference yield: 47.0%

benzyl bromide (100-39-0) + meta-aminobenzoic acid (99-05-8,159139-79-4) → 3-aminobenzoic acid benzyl ester (80787-43-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.8b01512

upstream raw materials:

3-nitrobenzoic acid benzyl ester

benzyl 3-(tert-butoxycarbonylamino) benzoate

meta-aminobenzoic acid

3-[(tert-butoxycarbonyl)amino]benzoic acid

Downstream raw materials:

benzyl N-Boc-D,L-m-Tyr(O-Pyrim)-m-aminobenzoate

benzyl N-Boc-Tyr(O-Pyrim)-m-aminobenzoate

3-((S)-2-Amino-3-phenyl-propionylamino)-benzoic acid benzyl ester

3-{[5-(2-Adamantan-1-yl-ethyl)-2-(2-dimethylamino-phenyl)-1H-imidazole-4-carbonyl]-amino}-benzoic Acid Benzyl Ester

Refernces

• 1、 Khan, Gul Shahzada,Dickson, Benjamin D.,Barker, David. "Synthesis of benzoic acids and polybenzamides containing tertiary alkylamino functionality". experimental part. p. 1790 - 1801. Retrieved 2012/03/11.
• 2、 Krauss, Juergen,Knorr, Veronika,Manhardt, Vera,Scheffels, Stefanie,Bracher, Franz. "Synthesis of platensimycin analogues and their antibiotic potency". experimental part. p. 386 - 392. Retrieved 2009/04/16.