1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol

Base Information

Chemical Name:1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol
CAS No.:80360-43-6
Molecular Formula:C₁₃H₇F₁₂IO₂
Molecular Weight:550.083
Hs Code.:
Mol file:80360-43-6.mol

Synonyms:4-methyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>iodobenzene;1,1,1,3,3,3-HEXAFLUORO-2-[3-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXY-PROPAN-2-YL)-2-IODO-5-METHYL-PHENYL]PROPAN-2-OL;

Suppliers and Price of 1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol

Chemical Property:

Boiling Point:373.7°Cat760mmHg
Flash Point:179.8°C
PSA：40.46000
Density:1.905g/cm³
LogP:5.22400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol

There total 4 articles about 1,1,1,3,3,3-hexafluoro-2-[3-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2 -yl)-2-iodo-5-methyl-phenyl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76220-89-8
1,4-dihydro-8-bromo-6-methyl-2,2-dimethyl-4,4-bis(trifluoromethyl)-2H-<3,1>benzoxazine

: 80360-43-6
4-methyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>iodobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 2.) -78 deg C, 15 min

2: 91 percent / conc. sulfuric acid / acetic acid; H₂O / 24 h / Heating

With n-butyllithium; sulfuric acid; In water; acetic acid;
DOI:10.1021/jo00345a026

Reference yield:

: 80360-42-5
1,4-dihydro-8-<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>-6-methyl-2,2-dimethyl-4,4-bis(trifluoromethyl)-2H-<3,1>benzoxazine

: 80360-43-6
4-methyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>iodobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / conc. sulfuric acid / acetic acid; H₂O / 24 h / Heating

With sulfuric acid; In water; acetic acid;
DOI:10.1021/jo00345a026

Reference yield:

: 80360-40-3
6-bromo-4-methyl-2-<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>aniline

: 80360-43-6
4-methyl-2,6-bis<1-hydroxy-1-(trifluoromethyl)-2,2,2-trifluoroethyl>iodobenzene

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / glacial acetic acid / benzene / 32 h / Heating

2: 1.) n-butyllithium / 1.) ether, hexane, -78 deg C, 2.) -78 deg C, 15 min

3: 91 percent / conc. sulfuric acid / acetic acid; H₂O / 24 h / Heating

With n-butyllithium; sulfuric acid; acetic acid; In water; acetic acid; benzene;
DOI:10.1021/jo00345a026