(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid
CAS No.:80896-73-7
Molecular Formula:C₁₈H₁₉NO₂
Molecular Weight:281.354
Hs Code.:2933990090
DSSTox Substance ID:DTXSID701001620
Mol file:80896-73-7.mol

Synonyms:(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid;SCHEMBL419234;DTXSID701001620;AKOS015856028;AKOS015898186;AM20041195;CS-0058378;J-524985;Trans-1-benzyl-4-phenylpyrrolidine-3-carboxylicacid;(3R*,4S*)-1-Benzyl-4-phenyl-pyrrolidine-3-carboxylic acid;3-yrrolidinecarboxyli acid, 4-henyl-1-(phenylmethyl)-, (3R,4S)-el-

Suppliers and Price of (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TRANS-1-BENZYL-4-PHENYLPYRROLIDINE-3-CARBOXYLIC ACID 95.00%
5G
$ 1899.98

Activate Scientific
trans-1-Benzyl-4-phenylpyrrolidine-3-carboxylicacid 95+%
1 g
$ 202.00

Total 25 raw suppliers

Chemical Property of (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

Chemical Property:

Vapor Pressure:7.59E-09mmHg at 25°C
PSA：40.54000
LogP:2.92470
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:281.141578849
Heavy Atom Count:21
Complexity:345

Purity/Quality:

97% ^*data from raw suppliers

TRANS-1-BENZYL-4-PHENYLPYRROLIDINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(CN1CC2=CC=CC=C2)C(=O)O)C3=CC=CC=C3
Isomeric SMILES:C1[C@@H]([C@H](CN1CC2=CC=CC=C2)C(=O)O)C3=CC=CC=C3

Technology Process of (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

There total 21 articles about (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 438492-33-2
(3R,4S)-methyl 1-benzyl-4-phenylpyrrolidine-3-carboxylate

: 1201574-92-6,80896-73-7,1821739-17-6
(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

Guidance literature:: (3R,4S)-methyl 1-benzyl-4-phenylpyrrolidine-3-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 4 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;

Reference yield: 96.0%

: ethyl (±)-trans-1-benzyl-4-phenylpyrrolidine-3-carboxylate

: 80896-73-7,1821739-17-6
trans-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid

Guidance literature:: With barium dihydroxide; In ethanol; for 15h; Heating;
DOI:10.1002/hlca.19810640727

Reference yield: 40.0%

: 951742-95-3
1-benzyl-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid

: 885958-91-8,80896-73-7,1821739-17-6
(3RS,4RS)-1-benzyl-4-phenyl-pyrrolidine-3-carboxylic acid

Guidance literature:: 1-benzyl-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid; With hydrogen; triethylamine; [(R)-2,2'-bis(diphenylphosphino)-6,6'-dimethylbiphenyl]ruthenium-diacetate; In methanol; at 80 ℃; for 42h; under 30003 Torr;

With sodium hydroxide; In methanol; tert-butyl methyl ether; water;

With hydrogenchloride; In water; at 0 ℃; pH=6; Product distribution / selectivity;