2-{[(4-Methoxyphenyl)methoxy]methyl}oxirane

Base Information

• Chemical Name: 2-{[(4-Methoxyphenyl)methoxy]methyl}oxirane
• CAS No.: 80910-01-6
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• DSSTox Substance ID: DTXSID20378874
• Nikkaji Number: J1.190.417C
• Mol file: 80910-01-6.mol

Synonyms:80910-01-6;2-{[(4-methoxyphenyl)methoxy]methyl}oxirane;2-{[(4-methoxybenzyl)oxy]methyl}oxirane;2-[(4-methoxyphenyl)methoxymethyl]oxirane;Oxirane, [[(4-methoxyphenyl)methoxy]methyl]-;2-(((4-Methoxybenzyl)oxy)methyl)oxirane;Glycidyl p-methoxybenzyl ether;4-methoxybenzyl glycidyl ether;SCHEMBL9234580;(4-Methoxybenzyl)glycidyl ether;DTXSID20378874;QWWVSLBMMUDNTB-UHFFFAOYSA-N;MFCD01569587;AKOS000246927;AKOS017268695;2-(((4-methoxybenzyl)oxy)methyl) oxirane;CS-0221553;FT-0756441;EN300-09431;Z56346896

Chemical Property of 2-{[(4-Methoxyphenyl)methoxy]methyl}oxirane

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COCC2CO2

Technology Process of 2-{[(4-Methoxyphenyl)methoxy]methyl}oxirane

There total 22 articles about 2-{[(4-Methoxyphenyl)methoxy]methyl}oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-methoxybenzyl chloride (824-94-2) + (S)-oxiranemethanol (60456-23-7) → (R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane (80910-01-6,108836-41-5,144069-33-0,134733-19-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201501877

Reference yield: 95.0%

p-Methoxybenzyl bromide (2746-25-0) + (R)-oxiranemethanol (57044-25-4) → (R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane (80910-01-6,108836-41-5,144069-33-0,134733-19-0)

Guidance literature:

(R)-oxiranemethanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 20h;

p-Methoxybenzyl bromide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.24820/ark.5550190.p010.461

Reference yield: 95.0%

p-Methoxybenzyl bromide (2746-25-0) + (S)-oxiranemethanol (60456-23-7) → (S)-2-[(4-methoxybenzyloxy)methyl]oxirane (80910-01-6,108836-41-5,134733-19-0,144069-33-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1135/cccc2008181

upstream raw materials:

1-(allyloxymethyl)-4-methoxybenzene

(R)-(-)-epichlorohydrin

4-Methoxybenzyl alcohol

p-methoxybenzyl chloride

Downstream raw materials:

(S)-4-Benzenesulfonyl-1-(4-methoxy-benzyloxy)-butan-2-ol

(2S)-1-[(4-methoxybenzyl)oxy]hex-5-yn-2-ol

tert-Butyl-[(S)-1-(4-methoxy-benzyloxymethyl)-3-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-but-3-enyloxy]-dimethyl-silane

[(S)-3-Benzenesulfonyl-1-(4-methoxy-benzyloxymethyl)-4-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-butoxy]-tert-butyl-dimethyl-silane