Technology Process of L-Alanine,
N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-L-valyl]-N-
methyl-L-leucyl]-, phenylmethyl ester
There total 20 articles about L-Alanine,
N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucyl]-L-valyl]-N-
methyl-L-leucyl]-, phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ja100517v
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
2: diethylamine / acetonitrile
3: 78 percent / diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphonic chloride / CH2Cl2 / 14 h / 5 °C
4: 100 percent / anisol, 5.8 M anhydrous HCl / dioxane / 1) 0 deg C, 2 h; 2) 5 deg C, 12 h
5: 1) diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 2) diisopropylethylamine / 1) CH2Cl2, 0 deg C, 2 h; 2) CH2Cl2, 6 deg C
With
hydrogenchloride; bis(2-oxo-3-oxazolidinyl)phosphoric acid chloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; methoxybenzene; diethylamine; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jo00296a061
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH2Cl2 / 0 °C
2: 50 percent trifluoroacetic acid / CH2Cl2 / 100 h / -18 - -13 °C
3: 78 percent / diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphonic chloride / CH2Cl2 / 14 h / 5 °C
4: 100 percent / anisol, 5.8 M anhydrous HCl / dioxane / 1) 0 deg C, 2 h; 2) 5 deg C, 12 h
5: 1) diisopropylethylamine, N,N'-bis(2-oxo-3-oxazolidinyl)phosphinic chloride, 2) diisopropylethylamine / 1) CH2Cl2, 0 deg C, 2 h; 2) CH2Cl2, 6 deg C
With
hydrogenchloride; bis(2-oxo-3-oxazolidinyl)phosphoric acid chloride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/jo00296a061